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http://hdl.handle.net/2445/186907
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DC Field | Value | Language |
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dc.contributor.author | Mompeon, Ana | - |
dc.contributor.author | Ortega Paz, Luis | - |
dc.contributor.author | Vidal Gomez, Xavier | - |
dc.contributor.author | Januario Costa, Tiago | - |
dc.contributor.author | Perez Cremades, Daniel | - |
dc.contributor.author | Garcia Blas, Sergio | - |
dc.contributor.author | Brugaletta, Salvatore | - |
dc.contributor.author | Sanchis Forés, Juan | - |
dc.contributor.author | Sabaté Tenas, Manuel | - |
dc.contributor.author | Novella, Susana | - |
dc.contributor.author | Dantas, Ana Paula | - |
dc.contributor.author | Hermenegildo, Carlos | - |
dc.date.accessioned | 2022-06-22T15:31:13Z | - |
dc.date.available | 2022-06-22T15:31:13Z | - |
dc.date.issued | 2020-03-25 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/2445/186907 | - |
dc.description.abstract | Despite the promising value of miRNAs in the diagnostic and prognostic of cardiovascular disease (CVD), recent meta-analyses did not support their potential. Methodological variances in studies may interfere with miRNA profle and afect their results. This study determines if the blood starting material is a source of variance in miRNA profle by performing a paired comparison in plasma and serum of the expression of primary miRNAs associated with CVD. Circulating miRNA yield was similar in both plasma and serum, although a signifcant increase was observed in patients with Non-ST-elevation myocardial infarction (NSTEMI) compared to control volunteers. When normalized by the expression of miR-484, diferent patterns of miRNA expression between serum and plasma. Although NSTEMI modifed the expression of miR-1 and miR-208 in both serum and plasma, plasma displayed a higher variance than serum (Levene's test p<0.01). For miR-133a and miR-26a, diferences were only detected in serum (p=0.0240), and conversely, miR-499a showed diferences only in plasma of NSTEMI (p=0.001). Interestingly, miR-21 showed an opposite pattern of expression, being increased in serum (2−ΔΔCt : 5.7, p=0.0221) and decreased in plasma (2−ΔΔCt : 0.5, p=0.0107). Plasma and serum exhibit diferent patterns of circulating miRNA expression in NSTEMI and suggest that results from studies with diferent starting material could not be comparable. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41598-020-61507-z | - |
dc.relation.ispartof | Scientific Reports, 2020, vol. 10, num. 1, p. 5373 | - |
dc.relation.uri | https://doi.org/10.1038/s41598-020-61507-z | - |
dc.rights | cc-by (c) Mompeon, Ana et al., 2020 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Vellesa | - |
dc.subject.classification | Micro RNAs | - |
dc.subject.classification | Infart de miocardi | - |
dc.subject.classification | Plasma sanguini | - |
dc.subject.other | Old age | - |
dc.subject.other | MicroRNAs | - |
dc.subject.other | Myocardial infarction | - |
dc.subject.other | Blood plasma | - |
dc.title | Disparate miRNA expression in serum and plasma of patients with acute myocardial infarction: a systematic and paired comparative analysis | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 715092 | - |
dc.date.updated | 2022-06-22T15:31:14Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32214121 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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File | Description | Size | Format | |
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715092.pdf | 1.43 MB | Adobe PDF | View/Open |
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