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Title: Dendrimersome Synthetic Cells Harbor Cell Division Machinery of Bacteria
Author: Wagner, Anna M.
Eto, Hiromune
Joseph, Anton
Kohyama, Shunshi
Haraszti, Tamás
Zamora, Ricardo A.
Vorobii, Mariia
Giannotti, Marina, I.
Schwille, Petra
Rodriguez Emmenegger, César
Keywords: Biomimètica
Issue Date: 6-Jun-2022
Publisher: Wiley
Abstract: The integration of active cell machinery with synthetic building blocks is the bridge toward developing synthetic cells with biological functions and beyond. Self-replication is one of the most important tasks of living systems, and various complex machineries exist to execute it. In Escherichia coli, a contractile division ring is positioned to mid-cell by concentration oscillations of self-organizing proteins (MinCDE), where it severs membrane and cell wall. So far, the reconstitution of any cell division machinery has exclusively been tied to liposomes. Here, the reconstitution of a rudimentary bacterial divisome in fully synthetic bicomponent dendrimersomes is shown. By tuning the membrane composition, the interaction of biological machinery with synthetic membranes can be tailored to reproduce its dynamic behavior. This constitutes an important breakthrough in the assembly of synthetic cells with biological elements, as tuning of membrane-divisome interactions is the key to engineering emergent biological behavior from the bottom-up.
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It is part of: Advanced Materials, 2022
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ISSN: 1521-4095
Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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