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DC Field | Value | Language |
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dc.contributor.author | Benítez, Iván D. | - |
dc.contributor.author | Batlle, Jordi de | - |
dc.contributor.author | Torres, Gerard | - |
dc.contributor.author | González, Jessica | - |
dc.contributor.author | Gonzalo Calvo, David de | - |
dc.contributor.author | Targa, Adriano D.S. | - |
dc.contributor.author | Gort Paniello, Clara | - |
dc.contributor.author | Moncusí Moix, Anna | - |
dc.contributor.author | Ceccato, Adrian | - |
dc.contributor.author | Fernández Barat, Laia | - |
dc.contributor.author | Ferrer, Ricard | - |
dc.contributor.author | Garcia Gasulla, Dario | - |
dc.contributor.author | Menéndez, Rosario | - |
dc.contributor.author | Motos, Anna | - |
dc.contributor.author | Peñuelas, Oscar | - |
dc.contributor.author | Riera, Jordi | - |
dc.contributor.author | Bermejo Martin, Jesús F. | - |
dc.contributor.author | Peñasco, Yhivian | - |
dc.contributor.author | Ricart, Pilar | - |
dc.contributor.author | Martin Delgado, María Cruz | - |
dc.contributor.author | Aguilera, Luciano | - |
dc.contributor.author | Rodríguez, Alejandro | - |
dc.contributor.author | Boado Varela, Maria Victoria | - |
dc.contributor.author | Suarez Sipmann, Fernando | - |
dc.contributor.author | Pozo Laderas, Juan Carlos | - |
dc.contributor.author | Solé Violán, Jordi | - |
dc.contributor.author | Nieto, Maite | - |
dc.contributor.author | Novo, Mariana Andrea | - |
dc.contributor.author | Barberán, José | - |
dc.contributor.author | Amaya Villar, Rosario | - |
dc.contributor.author | Garnacho Montero, José | - |
dc.contributor.author | García Garmendia, José Luis | - |
dc.contributor.author | Gómez, José M. | - |
dc.contributor.author | Lorente, José Ángel | - |
dc.contributor.author | Blandino Ortiz, Aaron | - |
dc.contributor.author | Tamayo Lomas, Luis | - |
dc.contributor.author | López Ramos, Esther | - |
dc.contributor.author | Úbeda, Alejandro | - |
dc.contributor.author | Catalán González, Mercedes | - |
dc.contributor.author | Sánchez Miralles, Angel | - |
dc.contributor.author | Martínez Varela, Ignacio | - |
dc.contributor.author | Jorge García, Ruth Noemí | - |
dc.contributor.author | Franco, Nieves | - |
dc.contributor.author | Gumucio Sanguino, Víctor D. | - |
dc.contributor.author | Huerta Garcia, Arturo | - |
dc.contributor.author | Bustamante Munguira, Elena | - |
dc.contributor.author | Valdivia, Luis Jorge | - |
dc.contributor.author | Caballero, Jesús | - |
dc.contributor.author | Gallego, Elena | - |
dc.contributor.author | Martínez de la Gándara, Amalia | - |
dc.contributor.author | Castellanos Ortega, Álvaro | - |
dc.contributor.author | Trenado, Josep | - |
dc.contributor.author | Marin Corral, Judith | - |
dc.contributor.author | Albaiceta, Guillermo M. | - |
dc.contributor.author | De La Torre, Maria Del Carmen | - |
dc.contributor.author | Loza-vázquez, Ana | - |
dc.contributor.author | Vidal, Pablo | - |
dc.contributor.author | Lopez Messa, Juan | - |
dc.contributor.author | Añón, José M. | - |
dc.contributor.author | Carbajales Pérez, Cristina | - |
dc.contributor.author | Sagredo, Víctor | - |
dc.contributor.author | Bofill, Neus | - |
dc.contributor.author | Carbonell, Nieves | - |
dc.contributor.author | Socias, Lorenzo | - |
dc.contributor.author | Barberà, Carme | - |
dc.contributor.author | Estella, Ángel | - |
dc.contributor.author | Valledor Mendez, Manuel | - |
dc.contributor.author | Diaz, Emili | - |
dc.contributor.author | López Lago, Ana | - |
dc.contributor.author | Torres, Antoni | - |
dc.contributor.author | Barbé, Ferran | - |
dc.contributor.author | CIBERESUCICOVID Project (COV20/00110, ISCIII) | - |
dc.date.accessioned | 2022-06-27T10:44:29Z | - |
dc.date.available | 2022-06-27T10:44:29Z | - |
dc.date.issued | 2022-06-01 | - |
dc.identifier.issn | 2666-7762 | - |
dc.identifier.uri | http://hdl.handle.net/2445/187027 | - |
dc.description.abstract | Background The clinical heterogeneity of COVID-19 suggests the existence of different phenotypes with prognostic implications. We aimed to analyze comorbidity patterns in critically ill COVID-19 patients and assess their impact on in-hospital outcomes, response to treatment and sequelae. Methods Multicenter prospective/retrospective observational study in intensive care units of 55 Spanish hospitals. 5866 PCR-confirmed COVID-19 patients had comorbidities recorded at hospital admission; clinical and biological parameters, in-hospital procedures and complications throughout the stay; and, clinical complications, persistent symptoms and sequelae at 3 and 6 months. Findings Latent class analysis identified 3 phenotypes using training and test subcohorts: low-morbidity (n=3385; 58%), younger and with few comorbidities; high-morbidity (n=2074; 35%), with high comorbid burden; and renal-morbidity (n=407; 7%), with chronic kidney disease (CKD), high comorbidity burden and the worst oxygenation profile. Renal-morbidity and high-morbidity had more in-hospital complications and higher mortality risk than low-morbidity (adjusted HR (95% CI): 1.57 (1.34-1.84) and 1.16 (1.05-1.28), respectively). Corticosteroids, but not tocilizumab, were associated with lower mortality risk (HR (95% CI) 0.76 (0.63-0.93)), especially in renal-morbidity and high-morbidity. Renal-morbidity and high-morbidity showed the worst lung function throughout the follow-up, with renal-morbidity having the highest risk of infectious complications (6%), emergency visits (29%) or hospital readmissions (14%) at 6 months (p<0.01). Interpretation Comorbidity-based phenotypes were identified and associated with different expression of in-hospital complications, mortality, treatment response, and sequelae, with CKD playing a major role. This could help clinicians in day-to-day decision making including the management of post-discharge COVID-19 sequelae. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd. | - |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.lanepe.2022.100422 | - |
dc.relation.ispartof | The Lancet Regional Health - Europe, 2022, vol. 18 | - |
dc.relation.uri | https://doi.org/10.1016/j.lanepe.2022.100422 | - |
dc.rights | cc by-nc-nd (c) Benítez, Iván D. et al, 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Comorbiditat | - |
dc.subject.classification | COVID-19 | - |
dc.subject.other | Comorbidity | - |
dc.subject.other | COVID-19 | - |
dc.title | Prognostic implications of comorbidity patterns in critically ill COVID-19 patients: A multicenter, observational study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-06-27T10:05:39Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 35655660 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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1-s2.0-S2666776222001168-main.pdf | 2.08 MB | Adobe PDF | View/Open |
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