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DC Field | Value | Language |
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dc.contributor.author | Rokx, Casper | - |
dc.contributor.author | Lammers, Jolanda | - |
dc.contributor.author | Buitenhuis, Lonneke | - |
dc.contributor.author | Postma, Douwe | - |
dc.contributor.author | Koster, David | - |
dc.contributor.author | Lukens, Michaèl | - |
dc.contributor.author | Scholtens, Thea | - |
dc.contributor.author | Boomgaard, Maartje van den | - |
dc.contributor.author | Kampschreur, Linda | - |
dc.contributor.author | Ubals, Maria | - |
dc.contributor.author | Prat, Núria | - |
dc.contributor.author | Díez Sánchez, Beatriz | - |
dc.contributor.author | Vértiz Guidotti, Thatiana | - |
dc.contributor.author | Pons Barber, Maria | - |
dc.contributor.author | Gonzalez Ruiz, Cristian | - |
dc.contributor.author | Navarrete Gonzalez, Laura | - |
dc.contributor.author | Ancochea, Àgueda | - |
dc.contributor.author | Ferrer, Magí | - |
dc.contributor.author | Videla, Sebas | - |
dc.contributor.author | Gudiol, Carlota | - |
dc.contributor.author | Fernández Rivas, Gema | - |
dc.contributor.author | CoV-Early Study Group | - |
dc.contributor.author | Vonderen, Marit van | - |
dc.contributor.author | Bianco, Andrea Sofia | - |
dc.contributor.author | Bravo, Anna | - |
dc.contributor.author | Otero, Aurema | - |
dc.contributor.author | Ruibal Suarez, Jose Carlos | - |
dc.contributor.author | Benavent, Sergio | - |
dc.contributor.author | Zarauza Pellejero, Alvaro | - |
dc.contributor.author | Línio, Rosa | - |
dc.contributor.author | Malchair, Pierre | - |
dc.contributor.author | Llopis Roca, Ferran | - |
dc.contributor.author | Blanco, Julian | - |
dc.contributor.author | Rodriguez Cortez, Orlando | - |
dc.contributor.author | Casares Gonzalez, Pablo | - |
dc.contributor.author | Arcos Vila, Gemma | - |
dc.contributor.author | García, Yolanda | - |
dc.contributor.author | Roca Font, Judit | - |
dc.contributor.author | Carrasco Matos, Katherine M. | - |
dc.contributor.author | Saüch Valmaña, Glòria | - |
dc.contributor.author | Vidal Obradors, Carla | - |
dc.contributor.author | Koopmans, Marion | - |
dc.contributor.author | Ara, Jordi | - |
dc.contributor.author | COnV-ert Study Group | - |
dc.contributor.author | Rodríguez Codina, Joana | - |
dc.contributor.author | Tarres García, Silvia | - |
dc.contributor.author | Blanco, Ignacio | - |
dc.contributor.author | Hernández, Águeda | - |
dc.contributor.author | González Soler, Victoria | - |
dc.contributor.author | Curriu Sabatès, Margarida | - |
dc.contributor.author | Nieto Rodríguez, Raquel | - |
dc.contributor.author | Grífols, Joan Ramon | - |
dc.contributor.author | Briones Zambrano, Ney Nicanor | - |
dc.contributor.author | Millan, Anna | - |
dc.contributor.author | Capdevila Jáuregui, Mar | - |
dc.contributor.author | Fornos, Miriam | - |
dc.contributor.author | Casamitjana, Natàlia | - |
dc.contributor.author | Bordoy, Antoni E. | - |
dc.contributor.author | Alonso, Eva | - |
dc.contributor.author | Zwet, Erik van | - |
dc.contributor.author | Miedema, Jelle | - |
dc.contributor.author | Martinez, Núria | - |
dc.contributor.author | Ramírez Morros, Anna | - |
dc.contributor.author | Bogers, Susanne | - |
dc.contributor.author | Maglio, Laura Analía | - |
dc.contributor.author | Amado Simon, Rosa | - |
dc.contributor.author | Comellas Fernandez, Laura | - |
dc.contributor.author | Garcia, Nadia | - |
dc.contributor.author | Ruiz Comellas, Anna | - |
dc.contributor.author | Baro, Bàrbara | - |
dc.contributor.author | Hernández, Luis | - |
dc.contributor.author | Viozquez Meya, Maria | - |
dc.contributor.author | Costes, Gèlia | - |
dc.contributor.author | Pradenas, Edwars | - |
dc.contributor.author | Forcada, Anna | - |
dc.contributor.author | Ginneken, Betty van | - |
dc.contributor.author | Harvala, Heli | - |
dc.contributor.author | Marfil, Silvia | - |
dc.contributor.author | Troxel, Andrea | - |
dc.contributor.author | Mooijaart, Simon | - |
dc.contributor.author | Trinité, Benjamin | - |
dc.contributor.author | Piccolo Ferreira, Francini | - |
dc.contributor.author | Bonet, Mireia | - |
dc.contributor.author | Cantoni, Jordi | - |
dc.contributor.author | Russcher, Henk | - |
dc.contributor.author | Marks, Michael | - |
dc.contributor.author | Zwaginga, Jaap Jan | - |
dc.contributor.author | Torrano Soler, Pamela | - |
dc.contributor.author | Mitjà, Oriol | - |
dc.contributor.author | Rijnders, Bart J. A. | - |
dc.contributor.author | Droog, José de | - |
dc.contributor.author | Corbacho Monné, Marc | - |
dc.contributor.author | Scherpenisse, Cees | - |
dc.contributor.author | Hollander, Jan den | - |
dc.contributor.author | Gharbharan, Arvind | - |
dc.contributor.author | Rokx, Casper | - |
dc.contributor.author | Jordans, Carlijn | - |
dc.contributor.author | Geurtsvankessel, Corine | - |
dc.contributor.author | Albersen, Arjan | - |
dc.contributor.author | Papageourgiou, Grigorios | - |
dc.contributor.author | Katsikis, Peter | - |
dc.contributor.author | Vall Mayans, Martí | - |
dc.contributor.author | Müller, Yvonne | - |
dc.contributor.author | Reusken, Chantal | - |
dc.contributor.author | San José, Alba | - |
dc.contributor.author | Ferrer, Susana | - |
dc.contributor.author | Engen, Rene van | - |
dc.contributor.author | Karisli, Ayten | - |
dc.contributor.author | Götz, Hannelore | - |
dc.contributor.author | Struik, Jelle | - |
dc.contributor.author | París, Alexa | - |
dc.contributor.author | Suñer Navarro, Clara | - |
dc.contributor.author | Clotet, Bonaventura, 1953- | - |
dc.contributor.author | Reimerink, Johan | - |
dc.contributor.author | Rokx-Niemantsverdriet, Lotte | - |
dc.contributor.author | Rodriguez Arias, Miquel Angel | - |
dc.contributor.author | Jiménez, Zahida | - |
dc.contributor.author | Verstijnen, Jose | - |
dc.contributor.author | Geloven, Nan van | - |
dc.contributor.author | Groeneveld, Geert | - |
dc.contributor.author | Zwaginga, Lisa | - |
dc.contributor.author | Oud, Josine | - |
dc.contributor.author | Meier, Romy | - |
dc.contributor.author | González Beiras, Camila | - |
dc.contributor.author | Swaneveld, Francis | - |
dc.contributor.author | Ramírez Viaplana, Ferran | - |
dc.contributor.author | Schoot, Ellen van der | - |
dc.contributor.author | Vrielink, Hans | - |
dc.contributor.author | Flores Aguilera, Begoña | - |
dc.contributor.author | Vivero Larraza, Ainhoa | - |
dc.contributor.author | Watering, Leo van de | - |
dc.contributor.author | Hogema, Boris | - |
dc.contributor.author | González García, David | - |
dc.contributor.author | Wijngaarden, Peter van | - |
dc.contributor.author | Vidal Alaball, Josep | - |
dc.contributor.author | Etten, Ronald van | - |
dc.contributor.author | Gammeren, Adriaan van | - |
dc.contributor.author | Alemany, Andrea | - |
dc.contributor.author | Puig, Jordi | - |
dc.contributor.author | Maas, Nanda | - |
dc.contributor.author | Berg – Rahman, Juliette van der | - |
dc.contributor.author | Karim, Faiz | - |
dc.contributor.author | Hiddema, Siepke | - |
dc.contributor.author | Elst, Kim van | - |
dc.contributor.author | García García, Vanesa | - |
dc.contributor.author | Casañ Lopez, Cristina | - |
dc.contributor.author | Leeuwen-Segarceanu, Elena van | - |
dc.contributor.author | Nieto, Aroa | - |
dc.contributor.author | Rodríguez Sevilla, Graciela | - |
dc.contributor.author | Reitsma, Annette | - |
dc.contributor.author | Molenkamp, Karin | - |
dc.contributor.author | Soetekouw, Robert | - |
dc.contributor.author | Band, Caterina | - |
dc.contributor.author | Carceles Peiró, Victor | - |
dc.contributor.author | Gallardo, Mireia | - |
dc.contributor.author | Galvan Femenia, Ivan | - |
dc.contributor.author | Comas Leon, Xavier | - |
dc.contributor.author | Millat Martínez, Pere | - |
dc.contributor.author | Bassat Orellana, Quique | - |
dc.contributor.author | González, María Isabel | - |
dc.contributor.author | Verdaguer, Joaquim | - |
dc.contributor.author | Roquer López, Clàudia | - |
dc.contributor.author | Contreras, Enric | - |
dc.contributor.author | Giménez, Montserrat | - |
dc.contributor.author | Ouchi, Dan | - |
dc.contributor.author | Blanco Guillermo, Ignacio | - |
dc.contributor.author | Bonet Papell, Glòria | - |
dc.contributor.author | Dastis Arias, Macarena | - |
dc.contributor.author | Delgado Capel, Maria | - |
dc.date.accessioned | 2022-06-27T10:25:57Z | - |
dc.date.available | 2022-06-27T10:25:57Z | - |
dc.date.issued | 2022-05-11 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/187056 | - |
dc.description.abstract | Data on convalescent plasma (CP) treatment in COVID-19 outpatients are scarce. We aimed to assess whether CP administered during the first week of symptoms reduced the disease progression or risk of hospitalization of outpatients. Two multicenter, double-blind randomized trials (NCT04621123, NCT04589949) were merged with data pooling starting when <20% of recruitment target was achieved. A Bayesian-adaptive individual patient data metaanalysis was implemented. Outpatients aged >= 50 years and symptomatic for <= 7days were included. The intervention consisted of 200-300mL of CP with a predefined minimum level of antibodies. Primary endpoints were a 5-point disease severity scale and a composite of hospitalization or death by 28 days. Amongst the 797 patients included, 390 received CP and 392 placebo; they had a median age of 58 years, 1 comorbidity, 5 days symptoms and 93% had negative IgG antibody-test. Seventy-four patients were hospitalized, 6 required mechanical ventilation and 3 died. The odds ratio (OR) of CP for improved disease severity scale was 0.936 (credible interval (CI) 0.667-1.311); OR for hospitalization or death was 0.919 (CI 0.592-1.416). CP effect on hospital admission or death was largest in patients with <= 5 days of symptoms (OR 0.658, 95%CI 0.394-1.085). CP did not decrease the time to full symptom resolution. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Science | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41467-022-29911-3 | - |
dc.relation.ispartof | Nature Communications, 2022, vol. 13, num. 1 | - |
dc.relation.uri | https://doi.org/10.1038/s41467-022-29911-3 | - |
dc.rights | cc by (c) Rokx, Casper et al, 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | COVID-19 | - |
dc.subject.classification | Immunoregulació | - |
dc.subject.other | COVID-19 | - |
dc.subject.other | Immunoregulation | - |
dc.title | Prospective individual patient data meta-analysis of two randomized trials on convalescent plasma for COVID-19 outpatients | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-06-23T11:35:25Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 35546145 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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s41467-022-29911-3.pdf | 1.46 MB | Adobe PDF | View/Open |
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