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DC Field | Value | Language |
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dc.contributor.author | Brown, Darron R. | - |
dc.contributor.author | Castellsagué, Xavier | - |
dc.contributor.author | Ferris, Daron | - |
dc.contributor.author | Garland, Suzanne M. | - |
dc.contributor.author | Huh, Warner | - |
dc.contributor.author | Steben, Marc | - |
dc.contributor.author | Wheeler, Cosette M. | - |
dc.contributor.author | Saah, Alfred | - |
dc.contributor.author | Luxembourg, Alain | - |
dc.contributor.author | Li, Se | - |
dc.contributor.author | Velicer, Christine | - |
dc.date.accessioned | 2022-06-27T10:55:19Z | - |
dc.date.available | 2022-06-27T10:55:19Z | - |
dc.date.issued | 2022-05-01 | - |
dc.identifier.issn | 2666-6790 | - |
dc.identifier.uri | http://hdl.handle.net/2445/187066 | - |
dc.description.abstract | Background: Estimates of the humoral immune response to incident human papillomavirus (HPV) infections are limited. Methods: In this post hoc analysis of 3875 women aged 16-23 years from a 4-valent HPV vaccine trial (NCT00092482), HPV seroprevalence on day 1 was measured with a 9-valent HPV (HPV 6/11/16/18/31/33/45/ 52/58) competitive Luminex immunoassay and compared with cervical/external genital HPV detection by po-lymerase chain reaction. In the control group, among women who were HPV DNA-negative on day 1, sero-conversion following initial HPV detection was estimated using Kaplan-Meier methods. Results: Type-specific HPV seropositivity among women with no day 1 cervical/external genital HPV detection was 0.6%-3.6%. Women with any 9-valent HPV (9vHPV) cervical/external genital detection (796/3875; 20.5%) had concordant seropositivity ranging from 13.4% (HPV 45) to 38.5% (HPV 6). Among women in the control group who were negative for all HPV types on day 1, seroconversion by month 30 after initial detection ranged from 29% (HPV 45) to 75% (HPV 16). Conclusions: Humoral immune response to HPV is variable and dynamic, depending on type-specific exposure. This longitudinal analysis provides insight into the relationship between incident infection and seropositivity. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1016/j.tvr.2022.200236 | - |
dc.relation.ispartof | Tumour Virus Research, 2022, vol. 13 | - |
dc.relation.uri | https://doi.org/10.1016/j.tvr.2022.200236 | - |
dc.rights | cc by-nc-nd (c) Brown, Darron R. et al, 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Papil·lomavirus | - |
dc.subject.classification | Genètica humana | - |
dc.subject.other | Papillomaviruses | - |
dc.subject.other | Human genetics | - |
dc.title | Human papillomavirus seroprevalence and seroconversion following baseline detection of nine human papillomavirus types in young women | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-06-27T07:57:54Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 35525430 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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1-s2.0-S2666679022000027-main.pdf | 947.48 kB | Adobe PDF | View/Open |
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