Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/187404
Title: | NRN1 Gene as a Potential Marker of Early-Onset Schizophrenia: Evidence from Genetic and Neuroimaging Approaches |
Author: | Almodóvar-Payá, Carmen Guardiola-Ripoll, Maria Giralt-López, Maria Gallego, Carme Salgado-Pineda, Pilar Miret, Salvador Salvador, Raymond Muñoz, María J. Lázaro García, Luisa Guerrero-Pedraza, Amalia Parellada, Mara Carrión, María I. Cuesta, Manuel J. Maristany, Teresa Sarró, Salvador Fañanás Saura, Lourdes Callado, Luis F. Arias Sampériz, Bárbara Pomarol-Clotet, Edith Fatjó-Vilas Mestre, Mar |
Keywords: | Imatges per ressonància magnètica Esquizofrènia Magnetic resonance imaging Schizophrenia |
Issue Date: | 5-Jul-2022 |
Publisher: | MDPI |
Abstract: | Included in the neurotrophins family, the Neuritin 1 gene (NRN1) has emerged as an attractive candidate gene for schizophrenia (SZ) since it has been associated with the risk for the disorder and general cognitive performance. In this work, we aimed to further investigate the association of NRN1 with SZ by exploring its role on age at onset and its brain activity correlates. First, we developed two genetic association analyses using a family-based sample (80 early-onset (EO) trios (offspring onset ≤ 18 years) and 71 adult-onset (AO) trios) and an independent case control sample (120 healthy subjects (HS), 87 EO and 138 AO patients). Second, we explored the effect of NRN1 on brain activity during a working memory task (N-back task; 39 HS, 39 EO and 39 AO; matched by age, sex and estimated IQ). Different haplotypes encompassing the same three Single Nucleotide Polymorphisms(SNPs, rs3763180 rs10484320 rs4960155) were associated with EO in the two samples (GCT, TCC and GTT). Besides, the GTT haplotype was associated with worse N-back task performance in EO and was linked to an inefficient dorsolateral prefrontal cortex activity in subjects with EO compared to HS. Our results show convergent evidence on the NRN1 association with EO both from genetic and neuroimaging approaches, highlighting the role of neurotrophins in the pathophysiology of SZ. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijms23137456 |
It is part of: | International Journal of Molecular Sciences, 2022, vol. 23, num. 13, p. 1-18 |
URI: | http://hdl.handle.net/2445/187404 |
Related resource: | https://doi.org/10.3390/ijms23137456 |
ISSN: | 1661-6596 |
Appears in Collections: | Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
724078.pdf | 1.05 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License