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Title: C-Reactive Protein and Serum Albumin Ratio: A Feasible Prognostic Marker in Hospitalized Patients with COVID-19
Author: Giner Galvañ, Vicente
Pomares Gómez, Francisco
Quesada, José Antonio
Rubio Rivas, Manuel
Tejada Montes, Javier
Baltasar Corral, Jesús
Taboada-Martínez, María Luisa
Sánchez Mesa, Blanca
Arnalich Fernández, Francisco
Corral Beamonte, Esther del
López Sampalo, Almudena
Pesqueira Fontán, Paula
Fernández Garcés, Mar
Gómez Huelgas, Ricardo
Ramos Rincón, José
SEMI-COVID-19 Network
Keywords: COVID-19
Issue Date: 13-Jun-2022
Publisher: MDPI
Abstract: Background: C-reactive protein (CRP) and albumin are inflammatory markers. We analyzed the prognostic capacity of serum albumin (SA) and CRP for an outcome comprising mortality, length of stay, ICU admission, and non-invasive mechanical ventilation in hospitalized COVID-19 patients. (2) Methods: We conducted a retrospective cohort study based on the Spanish national SEMI-COVID-19 Registry. Two multivariate logistic models were adjusted for SA, CRP, and their combination. Training and testing samples were used to validate the models. (3) Results: The outcome was present in 41.1% of the 3471 participants, who had lower SA (mean [SD], 3.5 [0.6] g/dL vs. 3.8 [0.5] g/dL; p < 0.001) and higher CRP (108.9 [96.5] mg/L vs. 70.6 [70.3] mg/L; p < 0.001). In the adjusted multivariate model, both were associated with poorer evolution: SA, OR 0.674 (95% CI, 0.551-0.826; p < 0.001); CRP, OR 1.002 (95% CI, 1.001-1.004; p = 0.003). The CRP/SA model had a similar predictive capacity (honest AUC, 0.8135 [0.7865-0.8405]), with a continuously increasing risk and cutoff value of 25 showing the highest predictive capacity (OR, 1.470; 95% CI, 1.188-1.819; p < 0.001). (4) Conclusions: SA and CRP are good independent predictors of patients hospitalized with COVID-19. For the CRP/SA ratio value, 25 is the cutoff for poor clinical course.
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It is part of: Biomedicines, 2022, vol. 10, num. 6
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ISSN: 2227-9059
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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