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http://hdl.handle.net/2445/187422
Title: | C-Reactive Protein and Serum Albumin Ratio: A Feasible Prognostic Marker in Hospitalized Patients with COVID-19 |
Author: | Giner Galvañ, Vicente Pomares Gómez, Francisco Quesada, José Antonio Rubio Rivas, Manuel Tejada Montes, Javier Baltasar Corral, Jesús Taboada-Martínez, María Luisa Sánchez Mesa, Blanca Arnalich Fernández, Francisco Corral Beamonte, Esther del López Sampalo, Almudena Pesqueira Fontán, Paula Fernández Garcés, Mar Gómez Huelgas, Ricardo Ramos Rincón, José SEMI-COVID-19 Network |
Keywords: | COVID-19 Comorbiditat COVID-19 Comorbidity |
Issue Date: | 13-Jun-2022 |
Publisher: | MDPI |
Abstract: | Background: C-reactive protein (CRP) and albumin are inflammatory markers. We analyzed the prognostic capacity of serum albumin (SA) and CRP for an outcome comprising mortality, length of stay, ICU admission, and non-invasive mechanical ventilation in hospitalized COVID-19 patients. (2) Methods: We conducted a retrospective cohort study based on the Spanish national SEMI-COVID-19 Registry. Two multivariate logistic models were adjusted for SA, CRP, and their combination. Training and testing samples were used to validate the models. (3) Results: The outcome was present in 41.1% of the 3471 participants, who had lower SA (mean [SD], 3.5 [0.6] g/dL vs. 3.8 [0.5] g/dL; p < 0.001) and higher CRP (108.9 [96.5] mg/L vs. 70.6 [70.3] mg/L; p < 0.001). In the adjusted multivariate model, both were associated with poorer evolution: SA, OR 0.674 (95% CI, 0.551-0.826; p < 0.001); CRP, OR 1.002 (95% CI, 1.001-1.004; p = 0.003). The CRP/SA model had a similar predictive capacity (honest AUC, 0.8135 [0.7865-0.8405]), with a continuously increasing risk and cutoff value of 25 showing the highest predictive capacity (OR, 1.470; 95% CI, 1.188-1.819; p < 0.001). (4) Conclusions: SA and CRP are good independent predictors of patients hospitalized with COVID-19. For the CRP/SA ratio value, 25 is the cutoff for poor clinical course. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/biomedicines10061393 |
It is part of: | Biomedicines, 2022, vol. 10, num. 6 |
URI: | http://hdl.handle.net/2445/187422 |
Related resource: | https://doi.org/10.3390/biomedicines10061393 |
ISSN: | 2227-9059 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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