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http://hdl.handle.net/2445/188135
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DC Field | Value | Language |
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dc.contributor.author | Meler Claramonte, Clara | - |
dc.contributor.author | Avilés Jurado, Francesc Xavier | - |
dc.contributor.author | Vilaseca González, Isabel | - |
dc.contributor.author | Terra, Ximena | - |
dc.contributor.author | Bragado, Paloma | - |
dc.contributor.author | Fuster Orellana, Gemma | - |
dc.contributor.author | León, Xavier | - |
dc.contributor.author | Camacho, Mercedes | - |
dc.date.accessioned | 2022-07-28T12:48:45Z | - |
dc.date.available | 2022-07-28T12:48:45Z | - |
dc.date.issued | 2022-04-30 | - |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | http://hdl.handle.net/2445/188135 | - |
dc.description.abstract | The expression of the semaphorin-3F (SEMA3F) and neuropilin-2 (NRP2) is involved in the regulation of lymphangiogenesis. The present study analyzes the relationship between the transcriptional expression of the SEMA3F-NRP2 genes and the presence of occult lymph node metastases in patients with cN0 head and neck squamous cell carcinomas. We analyzed the transcriptional expression of SEMA3F and NRP2 in a cohort of 53 patients with cN0 squamous cell carcinoma treated with an elective neck dissection. Occult lymph node metastases were found in 37.7% of the patients. Patients with occult lymph node metastases (cN0/pN+) had significantly lower SEMA3F expression values than patients without lymph node involvement (cN0/pN0). Considering the expression of the SEMA3F-NRP2 genes, patients were classified into two groups according to the risk of occult nodal metastasis: Group 1 (n = 34), high SEMA3F/low NRP2 expression, with a low risk of occult nodal involvement (14.7% cN0/pN+); Group 2 (n = 19), low SEMA3F or high SEMA3F/high NRP2 expression, with a high risk of occult nodal involvement (78.9% cN0/pN+). Multivariate analysis showed that patients in Group 2 had a 26.2 higher risk of lymph node involvement than patients in Group 1. There was a significant relationship between the transcriptional expression values of the SEMA3F-NRP2 genes and the risk of occult nodal metastases. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: | - |
dc.relation.ispartof | Cancers, 2022, vol. 14, num. 2259 | - |
dc.rights | cc-by (c) Meler Claramonte, Clara et al., 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Nodes limfàtics | - |
dc.subject.classification | Metàstasi | - |
dc.subject.classification | Càncer | - |
dc.subject.other | Lymph nodes | - |
dc.subject.other | Metastasis | - |
dc.subject.other | Cancer | - |
dc.title | Semaphorin-3F/Neuropilin-2 Transcriptional Expression as a Predictive Biomarker of Occult Lymph Node Metastases in HNSCC. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 724354 | - |
dc.date.updated | 2022-07-28T12:48:45Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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