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http://hdl.handle.net/2445/188340
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DC Field | Value | Language |
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dc.contributor.author | Grau, Laura | - |
dc.contributor.author | Romero, Manel | - |
dc.contributor.author | Privat-Contreras, Cristian | - |
dc.contributor.author | Presa, Daniela | - |
dc.contributor.author | Viñas, Miquel | - |
dc.contributor.author | Morral, Jordi | - |
dc.contributor.author | Pors, Klaus | - |
dc.contributor.author | Rubio Martínez, Jaime | - |
dc.contributor.author | Pujol Dilmé, M. Dolors | - |
dc.date.accessioned | 2022-08-23T09:01:32Z | - |
dc.date.available | 2022-08-23T09:01:32Z | - |
dc.date.issued | 2020-01-01 | - |
dc.identifier.issn | 0223-5234 | - |
dc.identifier.uri | http://hdl.handle.net/2445/188340 | - |
dc.description.abstract | An efficient four-step synthesis of tetracyclic lactones from 1,4-benzodioxine-2-carboxylic acid was developed. Ellipticine derivatives exhibit antitumor activity however only a few derivatives without carbazole subunit have been studied to date. Herein, several tetracyclic lactones were synthesized and biologically evaluated. Several compounds (2a, 3a, 4a and 5a) were found to be inhibitors of the KrasWnt pathway. The lactone 2a also exerted a potent inhibition of Tau protein translation and was shown to have capacity for CYP1A1-bioactivation. The results obtained are further evidence of the therapeutic potential of tetracyclic lactones related to ellipticine. Molecular modeling studies showed that compound 2a is inserted between helix a3 and a4 of the KRas protein making interactions with the hydrophobic residues Phe90, Glu91, Ile9364, Hie94, Leu133 and Tyr137and a hydrogen bond with residue Arg97. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Masson SAS | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1016/j.ejmech.2019.111807 | - |
dc.relation.ispartof | European Journal of Medicinal Chemistry, 2020, vol. 185, p. 111807 | - |
dc.relation.uri | https://doi.org/10.1016/j.ejmech.2019.111807 | - |
dc.rights | (c) Elsevier Masson SAS, 2020 | - |
dc.source | Articles publicats en revistes (Ciència dels Materials i Química Física) | - |
dc.subject.classification | Lactones | - |
dc.subject.classification | Models moleculars | - |
dc.subject.classification | Oncogens | - |
dc.subject.other | Lactones | - |
dc.subject.other | Molecular models | - |
dc.subject.other | Oncogenes | - |
dc.title | Multigram scale synthesis of polycyclic lactones and evaluation of antitumor and other biological properties | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 695083 | - |
dc.date.updated | 2022-08-23T09:01:32Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Institut de Química Teòrica i Computacional (IQTCUB)) Articles publicats en revistes (Ciència dels Materials i Química Física) |
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File | Description | Size | Format | |
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695083.pdf | 714.43 kB | Adobe PDF | View/Open |
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