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Title: | The pancreatic β-cell in ageing: Implications in age-related diabetes |
Author: | Tudurí, Eva Soriano, Sergi Almagro, Lucía Montanya Mias, Eduard Alonso Magdalena, Paloma Nadal, Ángel Quesada, Ivan |
Keywords: | Envelliment Diabetis Insulina Aging Diabetes Insulin |
Issue Date: | 1-Sep-2022 |
Publisher: | Elsevier BV |
Abstract: | The prevalence of type 2 diabetes (T2D) and impaired glucose tolerance (IGT) increases with ageing. T2D generally results from progressive impairment of the pancreatic islets to adapt fi-cell mass and function in the setting of insulin resistance and increased insulin demand. Several studies have shown an age-related decline in peripheral insulin sensitivity. However, a precise understanding of the pancreatic fi-cell response in ageing is still lacking. In this review, we summarize the age-related alterations, adaptations and/or failures of fi-cells at the molecular, morphological and functional levels in mouse and human. Age-associated alterations include processes such as fi-cell proliferation, apoptosis and cell identity that can influence fi-cell mass. Age-related changes also affect fi-cell function at distinct steps including electrical activity, Ca2+ signaling and insulin secretion, among others. We will consider the potential impact of these alterations and those mediated by senescence pathways on fi-cells and their implications in age-related T2D. Finally, given the great diversity of results in the field of fi-cell ageing, we will discuss the sources of this heterogeneity. A better understanding of fi-cell biology during ageing, particularly at older ages, will improve our insight into the contribution of fi-cells to ageassociated T2D and may boost new therapeutic strategies. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.arr.2022.101674 |
It is part of: | Ageing Research Reviews, 2022, vol. 80, p. 101674 |
URI: | http://hdl.handle.net/2445/188687 |
Related resource: | https://doi.org/10.1016/j.arr.2022.101674 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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