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http://hdl.handle.net/2445/188742
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DC Field | Value | Language |
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dc.contributor.author | Colini Baldeschi, Arianna | - |
dc.contributor.author | Zattoni, Marco | - |
dc.contributor.author | Vanni, Silvia | - |
dc.contributor.author | Nikolic, Lea | - |
dc.contributor.author | Ferracin, Chiara | - |
dc.contributor.author | La Sala, Giuseppina | - |
dc.contributor.author | Summa, Maria | - |
dc.contributor.author | Bertorelli, Rosalia | - |
dc.contributor.author | Bertozzi, Sine Mandrup | - |
dc.contributor.author | Giachin, Gabriele | - |
dc.contributor.author | Carloni, Paolo | - |
dc.contributor.author | Bolognesi, Maria Laura | - |
dc.contributor.author | De Vivo, Marco | - |
dc.contributor.author | Legname, Giuseppe | - |
dc.date.accessioned | 2022-09-06T12:49:34Z | - |
dc.date.available | 2022-09-06T12:49:34Z | - |
dc.date.issued | 2022-06-30 | - |
dc.identifier.uri | http://hdl.handle.net/2445/188742 | - |
dc.description.abstract | Prion diseases are a group of neurodegenerative disorders characterized by the accumulation of misfolded prion protein (called PrPSc). Although conversion of the cellular prion protein (PrPC) to PrPSc is still not completely understood, most of the therapies developed until now are based on blocking this process. Here, we propose a new drug strategy aimed at clearing prions without any direct interaction with neither PrPC nor PrPSc. Starting from the recent discovery of SERPINA3/SerpinA3n upregulation during prion diseases, we have identified a small molecule, named compound 5 (ARN1468), inhibiting the function of these serpins and effectively reducing prion load in chronically infected cells. Although the low bioavailability of this compound does not allow in vivo studies in prion-infected mice, our strategy emerges as a novel and effective approach to the treatment of prion disease. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Chemical Society (ACS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1021/acs.jmedchem.2c00205 | - |
dc.relation.ispartof | Journal of Medicinal Chemistry, 2022, vol. 65, num. 13, p. 8998-9010 | - |
dc.relation.uri | https://doi.org/10.1021/acs.jmedchem.2c00205 | - |
dc.rights | cc by (c) Colini Baldeschi, Arianna et al., 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Malalties per prions | - |
dc.subject.classification | Metabolisme | - |
dc.subject.classification | Prions | - |
dc.subject.other | Prion diseases | - |
dc.subject.other | Metabolism | - |
dc.subject.other | Prions | - |
dc.title | Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-08-04T13:55:07Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 35771181 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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jm2c00205.pdf | 6.35 MB | Adobe PDF | View/Open |
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