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Title: Antecedentes familiares de primer grado como factor de riesgo en el cáncer colorrectal
Author: Rubín García, María
Martín, Vicente
Vitelli Storelli, Facundo
Moreno Aguado, Víctor
Aragonés, Nuria
Ardanaz, Eva
Alonso Molero, Jéssica
Jiménez Moleón, José Juan
Amiano, Pilar
Fernández Tardón, Guillermo
Molina Barceló, Ana
Alguacil, Juan
Chirlaque, María Dolores
Álvarez Álvarez, Laura
Pérez Gómez, Beatriz
Dierssen Sotos, Trinidad
Olmedo Requena, Rocío
Guevara, Marcela
Fernández Villa, Tania
Pollán, Marina
Benavente, Yolanda
Keywords: Càncer colorectal
Factors de risc en les malalties
Malalties hereditàries
Colorectal cancer
Risk factors in diseases
Genetic diseases
Issue Date: 1-Jul-2021
Publisher: Elsevier BV
Abstract: Objective: To evaluate the association between first-degree family history and colorectal cancer (CRC). Method: We analyzed data from 2857 controls and 1360 CRC cases, collected in the MCC-Spain project. The adjusted odds ratio (OR) and 95% confidence interval (95% CI) of association with the family history of CRC was estimated by non-conditional logistic regression. Result: First-degree relatives doubled the risk of CRC (OR: 2.19; 95% CI: 1.80-2.66), increasing in those with two or more (OR: 4.22; 95% CI: 2.29-7.78) and in those whose relatives were diagnosed before 50 years (OR: 3.24; 95% CI: 1.52-6.91). Regarding the association of the family history with the location, no significant differences were observed between colon and rectum, but there were in the relation of these with the age of diagnosis, having more relatives those diagnosed before 50 years (OR: 4.79; 95% CI: 2.65-8.65). Conclusions: First-degree relatives of CRC increase the chances of developing this tumor, they also increase when the relative is diagnosed at an early age. Therefore, it must be a target population on which to carry out prevention measures.
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It is part of: Gaceta Sanitaria, 2021, vol. 36, num. 4, p. 345-352
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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