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http://hdl.handle.net/2445/188929
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DC Field | Value | Language |
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dc.contributor.author | Peremiquel-Trillas, Paula | - |
dc.contributor.author | Paytubi Casabona, Sònia | - |
dc.contributor.author | Pelegrina, Beatriz | - |
dc.contributor.author | Frias Gomez, Jon | - |
dc.contributor.author | Carmona, Álvaro | - |
dc.contributor.author | Martínez Delgado, José Manuel | - |
dc.contributor.author | Francisco, Javier de | - |
dc.contributor.author | Benavente, Yolanda | - |
dc.contributor.author | Barahona, Marc | - |
dc.contributor.author | Briansó, Ferran | - |
dc.contributor.author | Canet Hermida, Júlia | - |
dc.contributor.author | Caño, Víctor | - |
dc.contributor.author | Vidal, Augusto, 1909-1976 | - |
dc.contributor.author | Zanca, Alba | - |
dc.contributor.author | Baixeras, Núria | - |
dc.contributor.author | Rodríguez, Axel | - |
dc.contributor.author | Fernández Gonzalez, Sergi | - |
dc.contributor.author | Dueñas, Nuria | - |
dc.contributor.author | Càrdenas, Laura | - |
dc.contributor.author | Aytés Meneses, Álvaro | - |
dc.contributor.author | Bianchi, Ilaria | - |
dc.contributor.author | Pavón, Miquel Àngel | - |
dc.contributor.author | Reventós, Jaume | - |
dc.contributor.author | Capellá, G. (Gabriel) | - |
dc.contributor.author | Gómez, David, 1968- | - |
dc.contributor.author | Diaz, Mireia | - |
dc.contributor.author | Ponce, Jordi | - |
dc.contributor.author | Brunet, Joan | - |
dc.contributor.author | Matias-Guiu, Xavier | - |
dc.contributor.author | Bosch Font, Francesc | - |
dc.contributor.author | Sanjosé, Silvia de | - |
dc.contributor.author | Alemany, Laia | - |
dc.contributor.author | Pineda, Marta | - |
dc.contributor.author | Marin, Fátima | - |
dc.contributor.author | Costas, Laura | - |
dc.date.accessioned | 2022-09-12T10:51:19Z | - |
dc.date.available | 2022-09-12T10:51:19Z | - |
dc.date.issued | 2022-06-29 | - |
dc.identifier.issn | 2075-4426 | - |
dc.identifier.uri | http://hdl.handle.net/2445/188929 | - |
dc.description.abstract | Screenwide is a case-control study (2017-2021) including women with incident endometrial and ovarian cancers (EC and OC), BRCA1/2 and MMR pathogenic variant carriers, and age-matched controls from three centers in Spain. Participants completed a personal interview on their sociodemographic factors, occupational exposure, medication, lifestyle, and medical history. We collected biological specimens, including blood samples, self-collected vaginal specimens, cervical pap-brush samples, uterine specimens, and, when available, tumor samples. The planned analyses included evaluation of the potential risk factors for EC/OC; evaluation of molecular biomarkers in minimally invasive samples; evaluation of the cost-effectiveness of molecular tests; and the generation of predictive scores to integrate different epidemiologic, clinical, and molecular factors. Overall, 182 EC, 69 OC, 98 BRCA pathogenic variant carriers, 104 MMR pathogenic variant carriers, and 385 controls were enrolled. The overall participation rate was 85.7%. The pilot study using 61 samples from nine EC cases and four controls showed that genetic variants at the variant allele fraction > 5% found in tumors (n = 61 variants across the nine tumors) were detected in paired endometrial aspirates, clinician-collected cervical samples, and vaginal self-samples with detection rates of 90% (55/61), 79% (48/61), and 72% (44/61) by duplex sequencing, respectively. Among the controls, only one somatic mutation was detected in a cervical sample. We enrolled more than 800 women to evaluate new early detection strategies. The preliminary data suggest that our methodological approach could be useful for the early detection of gynecological cancers. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/jpm12071074 | - |
dc.relation.ispartof | Journal of Personalized Medicine, 2022, vol. 12, num. 7, p. 1074 | - |
dc.relation.uri | https://doi.org/10.3390/jpm12071074 | - |
dc.rights | cc by (c) Peremiquel-Trillas, Paula et al., 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer d'endometri | - |
dc.subject.classification | Càncer d'ovari | - |
dc.subject.classification | Genòmica | - |
dc.subject.other | Endometrial cancer | - |
dc.subject.other | Ovarian cancer | - |
dc.subject.other | Genomics | - |
dc.title | An Integrated Approach for the Early Detection of Endometrial and Ovarian Cancers (Screenwide Study): Rationale, Study Design and Pilot Study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-08-16T12:53:25Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 35887570 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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jpm-12-01074-v2.pdf | 1.07 MB | Adobe PDF | View/Open |
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