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Title: Association of time of breakfast and nighttime fasting duration with breast cancer risk in the multicase-control study in Spain
Author: Palomar Cros, Anna
Harding, Barbara N.
Espinosa, Ana
Papantoniou, Kyriaki
Pérez Gómez, Beatriz
Straif, Kurt
Ardanaz, Eva
Fernández Villa, Tania
Amiano, Pilar
Gómez Acebo, Inés
Moreno Aguado, Víctor
Alguacil, Juan
Fernández Tardón, Guillermo
Molina Barceló, Ana
Marcos Gragera, Rafael
Aragonés, Nuria
Castaño Vinyals, Gemma
Guevara, Marcela
Marcos Delgado, Alba
Pollán, Marina
Romaguera, Dora
Kogevinas, Manolis
Keywords: Càncer de mama
Factors de risc en les malalties
Ritmes circadiaris
Breast cancer
Risk factors in diseases
Circadian rhythms
Issue Date: 11-Aug-2022
Publisher: Frontiers Media SA
Abstract: Circadian nutritional behaviors, defined by the daily eating/fasting cycle, have been linked with breast cancer. This study aimed to further disentangle the association of nighttime fasting duration and time of breakfast with breast cancer risk. We analyzed data from 1,181 breast cancer cases and 1,326 population controls from the Spanish multicase-control study (MCC-Spain), 2008-2013. We collected circadian nutritional behaviors at mid-age via a telephonic interview. We applied logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CIs) for the association of nighttime fasting duration and time of breakfast with breast cancer risk in all women and stratified by menopausal status. Models were adjusted for age, center, education, family history of breast cancer, age at menarche, number of children, breastfeeding, age at first child, body mass index (BMI), contraceptive use, and hormonal replacement therapy (HRT). A later time of breakfast was associated with a non-significant increased risk of breast cancer (OR = 1.05, 95% CI: 0.95-1.16, per hour increase). This association was stronger among premenopausal women, among whom each hour later, the time of breakfast was associated with an 18% increase in breast cancer risk (OR = 1.18, 95% CI: 1.01-1.40). The association was not observed in postmenopausal women. We did not observe an association between nighttime fasting duration and breast cancer risk after adjusting for the time of breakfast. In this study, late breakfast was associated with increased breast cancer risk, especially among premenopausal women, compared with early breakfast. Aside from nutritional quality, circadian nutritional behaviors should be further studied in relation to cancer.
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It is part of: Frontiers in Nutrition, 2022, vol.9, num. 941477
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ISSN: 2296-861X
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (ISGlobal)

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