Please use this identifier to cite or link to this item:
Title: Mortality and biochemical recurrence after surgery, brachytherapy, or external radiotherapy for localized prostate cancer: a 10-year follow-up cohort study
Author: Suárez, José Francisco
Zamora, Víctor
Garin, Olatz
Hervás, Asunción
Ponce de León, Javier
Guedea, Ferran
Vigués, Francesc
Castells, Manuel
Ferrer Santanach, Montserrat
Pont, Àngels
Pardo, Yolanda
Alonso Caballero, Jordi
Zamora, Víctor
Ventura i Oller, Montserrat
Gutiérrez, Cristina
Ferrer, Ferran
Boladeras, Ana
Bonet Felipe, Xavier
Ávila, Mónica
Pastor, Sergi
Bonet, Carmen
Sancho, Gemma
Palou, Joan
Paula, Belén de
Goñi, Alai
Fernández, Pablo, 1957-
Herruzo, Ismael
Ramos, Alfredo, 1951-
Macías, Víctor
Solé, Josep
Bonet, Marta
Mariño, Alfonso
Cabrera, Patricia
Ortiz, María José
Multicentric Spanish Group Of Clinically Localized Prostate Cancer
Keywords: Assaigs clínics
Càncer de pròstata
Cirugía de la próstata
Clinical trials
Prostate cancer
Prostate surgery
Issue Date: 22-Jul-2022
Publisher: Springer Science and Business Media LLC
Abstract: To compare the effectiveness at ten years of follow-up of radical prostatectomy, brachytherapy and external radiotherapy, in terms of overall survival, prostate cancer-specific mortality and biochemical recurrence. Cohort of men diagnosed with localized prostate cancer (T1/T2 and low/intermediate risk) from ten Spanish hospitals, followed for 10 years. The treatment selection was decided jointly by patients and physicians. Of 704 participants, 192 were treated with open radical retropubic prostatectomy, 317 with I-125 brachytherapy alone, and 195 with 3D external beam radiation. We evaluated overall survival, prostate cancer-specific mortality, and biochemical recurrence. Kaplan-Meier estimators were plotted, and Cox proportional-hazards regression models were constructed to estimate hazard ratios (HR), adjusted by propensity scores. Of the 704 participants, 542 patients were alive ten years after treatment, and a total of 13 patients have been lost during follow-up. After adjusting by propensity score and Gleason score, brachytherapy and external radiotherapy were not associated with decreased 10-year overall survival (aHR = 1.36, p = 0.292 and aHR = 1.44, p = 0.222), but presented higher biochemical recurrence (aHR = 1.93, p = 0.004 and aHR = 2.56, p < 0.001) than radical prostatectomy at ten years of follow-up. Higher prostate cancer-specific mortality was also observed in external radiotherapy (aHR = 9.37, p = 0.015). Novel long-term results are provided on the effectiveness of brachytherapy to control localized prostate cancer ten years after treatment, compared to radical prostatectomy and external radiotherapy, presenting high overall survival, similarly to radical prostatectomy, but higher risk of biochemical progression. These findings provide valuable information to facilitate shared clinical decision-making.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2022, vol. 12, num. 1, p.12589
Related resource:
ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

Files in This Item:
File Description SizeFormat 
s41598-022-16395-w.pdf1.66 MBAdobe PDFView/Open

This item is licensed under a Creative Commons License Creative Commons