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Title: Exonucleases: degrading DNA to deal with genome damage, cell death, inflammation and cancer
Author: Manils Pacheco, Joan
Marruecos, Laura
Soler Prat, Concepció
Keywords: ADN
Genoma humà
Human genome
Issue Date: 9-Jul-2022
Publisher: MDPI
Abstract: Although DNA degradation might seem an unwanted event, it is essential in many cellular processes that are key to maintaining genomic stability and cell and organism homeostasis. The capacity to cut out nucleotides one at a time from the end of a DNA chain is present in enzymes called exonucleases. Exonuclease activity might come from enzymes with multiple other functions or specialized enzymes only dedicated to this function. Exonucleases are involved in central pathways of cell biology such as DNA replication, repair, and death, as well as tuning the immune response. Of note, malfunctioning of these enzymes is associated with immune disorders and cancer. In this review, we will dissect the impact of DNA degradation on the DNA damage response and its links with inflammation and cancer.
Note: Reproducció del document publicat a:
It is part of: Cells, 2022, vol. 11, num. 14
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ISSN: 2073-4409
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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