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http://hdl.handle.net/2445/189186
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DC Field | Value | Language |
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dc.contributor.author | Mesquida Veny, Francina | - |
dc.contributor.author | Martínez Torres, Sara | - |
dc.contributor.author | del Río, José Antonio | - |
dc.contributor.author | Hervera, Arnau | - |
dc.date.accessioned | 2022-09-20T09:38:40Z | - |
dc.date.available | 2022-09-20T09:38:40Z | - |
dc.date.issued | 2022-08-17 | - |
dc.identifier.citation | Mesquida-Veny, Francina;Martínez-Torres, Sara;del Rio, Jose Antonio;Hervera, Arnau. Genetic control of neuronal activity enhances axonal growth only on permissive substrates. Molecular Medicine, 2022, 28, 1-97 | - |
dc.identifier.issn | 1528-3658 | - |
dc.identifier.uri | http://hdl.handle.net/2445/189186 | - |
dc.description.abstract | Abstract Background Neural tissue has limited regenerative ability. To cope with that, in recent years a diverse set of novel tools has been used to tailor neurostimulation therapies and promote functional regeneration after axonal injuries. Method In this report, we explore cell-specific methods to modulate neuronal activity, including opto- and chemogenetics to assess the effect of specific neuronal stimulation in the promotion of axonal regeneration after injury. Results Opto- and chemogenetic stimulations of neuronal activity elicited increased in vitro neurite outgrowth in both sensory and cortical neurons, as well as in vivo regeneration in the sciatic nerve, but not after spinal cord injury. Mechanistically, inhibitory substrates such as chondroitin sulfate proteoglycans block the activity induced increase in axonal growth. Conclusions We found that genetic modulations of neuronal activity on both dorsal root ganglia and corticospinal motor neurons increase their axonal growth capacity but only on permissive environments. | - |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.relation.isformatof | https://doi.org/10.1186/s10020-022-00524-2 | - |
dc.relation.ispartof | Molecular Medicine, 2022, 28, 1-97 | - |
dc.relation.uri | https://doi.org/10.1186/s10020-022-00524-2 | - |
dc.rights | cc by (c) Mesquida Veny, Francina et al., 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) | - |
dc.subject.classification | Axons | - |
dc.subject.classification | Lesions medul·lars | - |
dc.subject.other | Axons | - |
dc.subject.other | Spinal cord injuries | - |
dc.title | Genetic control of neuronal activity enhances axonal growth only on permissive substrates | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-09-20T08:39:25Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.idimarina | 6566003 | - |
dc.identifier.pmid | 35978278 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
Files in This Item:
File | Description | Size | Format | |
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2022_MolMed_Genetic_HerveraA.pdf | 1.97 MB | Adobe PDF | View/Open |
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