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http://hdl.handle.net/2445/189206
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DC Field | Value | Language |
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dc.contributor.author | Lobatón, Triana | - |
dc.contributor.author | Azuara García, Daniel | - |
dc.contributor.author | Rodríguez Moranta, Francisco | - |
dc.contributor.author | Loayza, Carolina | - |
dc.contributor.author | Sanjuan, Xavier | - |
dc.contributor.author | Oca Burguete, Javier de | - |
dc.contributor.author | Fernández-Robles, Ana | - |
dc.contributor.author | Guardiola, Jordi | - |
dc.contributor.author | Capellá, G. (Gabriel) | - |
dc.date.accessioned | 2022-09-21T17:54:55Z | - |
dc.date.available | 2022-09-21T17:54:55Z | - |
dc.date.issued | 2014-08-14 | - |
dc.identifier.issn | 1007-9327 | - |
dc.identifier.uri | http://hdl.handle.net/2445/189206 | - |
dc.description.abstract | AIM: To investigate the relationship between the methylation status in the SLIT2 and TGFB2 promoters and colonic inflammation in inflammatory bowel disease patients. METHODS: We evaluated the methylation status of 2 genes (SLIT2 and TGFB2) in 226 biopsies taken from 62 colonoscopies of 38 patients (29 ulcerative colitis and 9 Crohn's colitis) using methylation-specific melting curve analysis. The relationships between methylation status and clinical, biological, endoscopic and histological activities were evaluated. Twenty-three of the 38 patients had a second colonoscopy and were included in a longitudinal analysis. Numerical results were given as the means ± SD of the sample and range, except when specified. Student t analysis, U Mann Whitney and ANOVA factor were used to compare the means. Qualitative results were based on the χ2 test. RESULTS: SLIT2 methylation was more frequent in samples with endoscopic activity than with endoscopic remission (55% vs 18%, P < 0.001). SLIT2 methylation was also higher in samples with acute inflammation (56.5%) than in samples with chronic (24%) or absent inflammation (15%) (P < 0.001). For TGFB2 methylation, the correlation was only significant with endoscopic activity. Methylation was higher in the distal colon for both genes (P < 0.001 for SLIT2 and P = 0.022 for TGFB2). In the multivariate analysis, only inflammation status (and not disease duration or extension) was independently associated with SLIT2 methylation [OR = 6.6 (95%CI: 1.65-27.36), P = 0.009]. In the longitudinal analysis, the maintenance of endoscopic remission was protective for methylation. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Baishideng Publishing Group Inc | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3748/wjg.v20.i30.10591 | - |
dc.relation.ispartof | World Journal of Gastroenterology, 2014, vol. 20, num. 30, p. 10591-10598 | - |
dc.relation.uri | https://doi.org/10.3748/wjg.v20.i30.10591 | - |
dc.rights | cc-by-nc (c) Lobatón, Triana et al., 2014 | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Inflamació | - |
dc.subject.classification | Colitis | - |
dc.subject.classification | Càncer colorectal | - |
dc.subject.classification | Malalties del còlon | - |
dc.subject.other | Inflammation | - |
dc.subject.other | Colitis | - |
dc.subject.other | Colorectal cancer | - |
dc.subject.other | Colonic diseases | - |
dc.title | Relationship between methylation and colonic inflammation in inflammatory bowel disease | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 676334 | - |
dc.date.updated | 2022-09-21T17:54:55Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 25132780 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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676334.pdf | 1.22 MB | Adobe PDF | View/Open |
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