Please use this identifier to cite or link to this item:
Title: Interstitial pulmonary fibrosis with and without associated collagen vascular diseases: results of a two year follow up
Author: Agustí, C.
Xaubet Mir, Antonio
Agustí, A. G. N.
Roca, Josep
Rodríguez-Roisin, Robert
Keywords: Fibrosi pulmonar
Fisiologia patològica
Pulmonary fibrosis
Collagen diseases
Pathological physiology
Issue Date: 1992
Publisher: BMJ Publishing Group
Abstract: Background: Interstitial pulmonary fibrosis is a disease with a highly variable clinical course. To ascertain if an inadequate selection of patients might explain part of this variability, two different groups of patients with interstitial pulmonary fibrosis, those with the 'lone' form of the disease (LIPF) and those with associated collagen vascular disorders (AIPF), were studied separately. Methods: Twenty consecutive patients (nine with LIPF and 11 with AIPF) were included. Their clinical and radiographic findings and results of pulmonary function tests, gallium-67 lung scanning, and cellular analysis of bronchoalveolar lavage fluid were compared at diagnosis. Moreover, the evolution of LIPF and AIPF was contrasted after a follow up of two years, both groups having received a similar treatment regimen of corticosteroids. Results: At enrollment, patients with LIPF and AIPF were of similar age, and had similar symptoms and derangement of lung function, but patients with LIPF presented with finger clubbing, more obvious radiographic abnormalities, and a greater percentage of eosinophils in bronchoalveolar lavage fluid. Two years later, patients with LIPF had significantly decreased FVC, FEV1, TLC, TLCO, and PaO2. By contrast, lung function remained unaltered in patients with AIPF. Similarly, when the percentage change from entry to the study was compared, patients with LIPF showed a significant decrease in FVC, FEV1, and PaO2. Conclusions: Unlike the patients with AIPF, those with LIPF showed a deterioration in lung function and developed further restrictive impairment and poorer gas exchange. This has implications in their clinical management.
Note: Reproducció del document publicat a:
It is part of: Thorax, 1992, vol. 47, num. 12, p. 1035-1040
Related resource:
ISSN: 0040-6376
Appears in Collections:Articles publicats en revistes (Medicina)

Files in This Item:
File Description SizeFormat 
072278.pdf1.07 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.