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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/189320
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dc.contributor.authorGinex, Tiziana-
dc.contributor.authorMarco Marín, Clara-
dc.contributor.authorWieczór, Miłosz-
dc.contributor.authorMata, Carlos P.-
dc.contributor.authorKrieger, James-
dc.contributor.authorRuiz Rodriguez, Paula-
dc.contributor.authorLópez Redondo, Maria Luisa-
dc.contributor.authorFrancés Gómez, Clara-
dc.contributor.authorMelero, Roberto-
dc.contributor.authorSánchez Sorzano, Carlos Óscar-
dc.contributor.authorMartínez, Marta-
dc.contributor.authorGougeard, Nadine-
dc.contributor.authorForcada Nadal, Alicia-
dc.contributor.authorZamora Caballero, Sara-
dc.contributor.authorGozalbo Rovira, Roberto-
dc.contributor.authorSanz Frasquet, Carla-
dc.contributor.authorArranz, Rocío-
dc.contributor.authorBravo, Jeronimo-
dc.contributor.authorRubio, Vicente-
dc.contributor.authorMarina, Alberto-
dc.contributor.authorGeller, Ron-
dc.contributor.authorComas, Iñaki-
dc.contributor.authorGil, Carmen-
dc.contributor.authorCoscolla, Mireia-
dc.contributor.authorOrozco López, Modesto-
dc.contributor.authorLlácer, José Luis-
dc.contributor.authorCarazo, Jose Maria-
dc.contributor.authorThe IBV Covid19 Pipeline-
dc.date.accessioned2022-09-23T07:41:26Z-
dc.date.available2022-09-23T07:41:26Z-
dc.date.issued2022-07-11-
dc.identifier.issn1553-7374-
dc.identifier.urihttp://hdl.handle.net/2445/189320-
dc.description.abstractThe S:A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared in the Delta subvariant AY.4.2, raising questions about its specific effect on viral infection. We report combined serological, functional, structural and computational studies characterizing the impact of this mutation. Our results reveal that S:A222V promotes an increased RBD opening and slightly increases ACE2 binding as compared to the parent S:D614G clade. Finally, S:A222V does not reduce sera neutralization capacity, suggesting it does not affect vaccine effectiveness.-
dc.format.extent28 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1371/journal.ppat.1010631-
dc.relation.ispartofPlos Pathogens, 2022, vol. 18, num. 7-
dc.relation.urihttps://doi.org/10.1371/journal.ppat.1010631-
dc.rightscc by (c) Ginex, Tiziana et al., 2022-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourceArticles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))-
dc.subject.classificationSARS-CoV-2-
dc.subject.classificationMutació (Biologia)-
dc.subject.otherSARS-CoV-2-
dc.subject.otherMutation (Biology)-
dc.titleThe structural role of SARS-CoV-2 genetic background in the emergence and success of spike mutations: The case of the spike A222V mutation-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.date.updated2022-09-23T07:21:03Z-
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/101001038/EU//TB-RECONNECT-
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/101024130/EU//EnLaCES-
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/810057/EU//HighResCells-
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/871037/EU//iNEXT-Discovery-
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/894489/EU//EPIDNA-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.idimarina6555936-
dc.identifier.pmid35816514-
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