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Title: Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region
Author: Ciampa, Iacopo
Operto, Grégory
Falcón, Carles
Minguillón Gil, Carolina
Castro de Moura, Manuel
Piñeyro, David
Esteller, Manel
Molinuevo, José Luis
Guigó Serra, Roderic
Navarro, Arcadi
Gispert, Juan Domingo
Vilor-Tejedor, Natalia
Keywords: Neurogenètica
Malaltia d'Alzheimer
Anàlisi multivariable
Alzheimer's disease
Multivariate analysis
Issue Date: 27-May-2021
Publisher: MDPI
Abstract: This study investigated whether genetic factors involved in Alzheimer's disease (AD) are associated with enlargement of Perivascular Spaces (ePVS) in the brain. A total of 680 participants with T2-weighted MRI scans and genetic information were acquired from the ALFA study. ePVS in the basal ganglia (BG) and the centrum semiovale (CS) were assessed based on a validated visual rating scale. We used univariate and multivariate logistic regression models to investigate associations between ePVS in BG and CS with BIN1-rs744373, as well as APOE genotypes. We found a significant association of the BIN1-rs744373 polymorphism in the CS subscale (p value = 0.019; OR = 2.564), suggesting that G allele carriers have an increased risk of ePVS in comparison with A allele carriers. In stratified analysis by APOE-#4 status (carriers vs. non-carriers), these results remained significant only for '4 carriers (p value = 0.011; OR = 1.429). To our knowledge, the present study is the first suggesting that genetic predisposition for AD is associated with ePVS in CS. These findings provide evidence that underlying biological processes affecting AD may influence CS-ePVS.
Note: Reproducció del document publicat a:
It is part of: Genes, 2021, vol. 12, num. 6
Related resource:
ISSN: 2073-4425
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

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