Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/189441
Title: Atypical carcinoid tumours of the lung: prognostic factors and patterns of recurrence
Author: Cañizares, M.A.
Matilla, J. M.
Cueto, A.
Algar, J.
Muguruza, I.
Moreno-Mata, N.
Moreno-Balsalobre, R.
Guijarro, R.
Arrabal, R.
Garcia-Fontan, E.
Gonzalez-Piñeiro, A.
Garcia-Yuste, M.
EMETNE-SEPAR Members
Moya Amorós, Juan
Keywords: Tumors
Càncer de pulmó
Biòpsia
Broncoscòpia
Tumors
Lung cancer
Biopsy
Bronchoscopy
Issue Date: 6-Mar-2014
Publisher: BMJ Publishing Group
Abstract: Background: Atypical carcinoids (AC) of the lung are rare intermediate-grade neuroendocrine neoplasms. Prognostic factors for these tumours are undefined. Methods: Our cooperative group retrieved data on 127 patients operated between 1980 and 2009 because of an AC. Several clinical and pathological features were studied. Results: In a univariable analysis, T-status (p=0.005), N-status (p=0.021), preoperative M-status (previously treated) (p=0.04), and distant recurrence developed during the outcome (p<0.001) presented statistically significant differences related to survival of these patients. In a multivariable analysis, only distant recurrence was demonstrated to be an independent risk factor for survival (p<0.001; HR: 13.1). During the monitoring, 25.2% of the patients presented some kind of recurrence. When we studied recurrence factors in a univariable manner, sublobar resections presented significant relationship with locoregional recurrence (p<0.001). In the case of distant recurrence, T and N status presented significant differences. Patients with preoperative M1 status presented higher frequencies of locoregional and distant recurrence (p=0.004 and p<0.001, respectively). In a multivariable analysis, sublobar resection was an independent prognostic factor to predict locoregional recurrence (p=0.002; HR: 18.1). Conclusions: Complete standard surgical resection with radical lymphadenectomy is essential for AC. Sublobar resections are related to locoregional recurrence, so they should be avoided except for carefully selected patients. Nodal status is an important prognostic factor to predict survival and recurrence. Distant recurrence is related to poor outcome.
Note: Reproducció del document publicat a: https://doi.org/10.1136/thoraxjnl-2013-204102
It is part of: Thorax, 2014, vol. 69, p. 648-653
URI: http://hdl.handle.net/2445/189441
Related resource: https://doi.org/10.1136/thoraxjnl-2013-204102
ISSN: 0040-6376
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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