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Title: Adherence to mediterranean diet and the risk of differentiated thyroid cancer in a European cohort: The EPIC study
Author: Llaha, Fjorida
Cayssials, Valerie
Farràs, Marta
Agudo, Antonio
Sandström, Maria
Eriksen, Anne Kirstine
Tjønneland, Anne
Boutron-ruault, Marie-christine
Laouali, Nasser
Truong, Thérèse
Le Cornet, Charlotte
Katzke, Verena
Schulze, Matthias
Palli, Domenico
Krogh, Vittorio
Signoriello, Simona
Tumino, Rosario
Ricceri, Fulvio
Skeie, Guri
Jensen, Torill Miriam Enget
Chen, Sairah Lai Fa
Lasheras, Cristina
Rodriguez Barranco, Miguel
Amiano, Pilar
Huerta, José María
Guevara, Marcela
Almquist, Martin
Nilson, Lena Maria
Hennings, Joakim
Papier, Keren
Heath, Alicia
Weiderpass, Elisabete
Rinaldi, Sabina
Zamora-Ros, Raul
Keywords: Cuina mediterrània
Càncer de tiroide
Mediterranean cooking
Thyroid gland cancer
Issue Date: 2-Sep-2022
Publisher: Frontiers Media SA
Abstract: BackgroundThe Mediterranean diet (MD) has been proposed as a healthy diet with a potential to lower the incidence of several types of cancer, but there is no data regarding thyroid cancer (TC). We investigated the association between MD adherence, and its components, and the differentiated TC risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. MethodsOver 450,000 men and women from nine European countries were followed up for a mean of 14.1 years, during which 712 differentiated TC cases were identified. Adherence to MD was estimated using the relative MD (rMED) score, an 18-point scale including alcohol, and the adapted rMED (arMED) score, a 16-point scale excluding alcohol. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models adjusted for potential confounding factors. ResultsAdherence to the arMED score was not associated with the risk of differentiated TC (HRhigh vs. low adherence = 0.94, 95% CI: 0.70-1.25; p-trend 0.27), while a suggestive, but non-statistically significant inverse relationship was observed with rMED (HRhigh vs. low adherence = 0.88, 95% CI: 0.68-1.14; p-trend 0.17). Low meat (HRlow vs. high meat intake = 0.81, 95% CI: 0.67-0.99; p-trend = 0.04) and moderate alcohol (HRmoderate vs. non-moderate intake = 0.88, 95% CI: 0.75-1.03) intake were related with lower differentiated TC risk. ConclusionsOur study shows that a high adherence to MD is not strongly related to differentiated TC risk, although further research is required to confirm the impact of MD and, especially, meat intake in TC risk.
Note: Reproducció del document publicat a:
It is part of: Frontiers in Nutrition, 2022, vol. 9
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ISSN: 2296-861X
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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