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http://hdl.handle.net/2445/189565
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DC Field | Value | Language |
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dc.contributor.author | Resina, Elena | - |
dc.contributor.author | Donday, María G. | - |
dc.contributor.author | Martínez Domínguez, Samuel J. | - |
dc.contributor.author | Laserna Mendieta, Emilio José | - |
dc.contributor.author | Lanas, Ángel | - |
dc.contributor.author | Lucendo, Alfredo J. | - |
dc.contributor.author | Sánchez Luengo, Marta | - |
dc.contributor.author | Alcaide, Noelia | - |
dc.contributor.author | Fernández Salazar, Luis | - |
dc.contributor.author | De La Peña Negro, Luisa | - |
dc.contributor.author | Bujanda, Luis | - |
dc.contributor.author | Arbulo, Marta Gómez Ruiz De | - |
dc.contributor.author | Alcedo, Javier | - |
dc.contributor.author | Pérez Aisa, Ángeles | - |
dc.contributor.author | Rodríguez, Raúl | - |
dc.contributor.author | Hermida, Sandra | - |
dc.contributor.author | Brenes, Yanire | - |
dc.contributor.author | Nyssen, Olga P. | - |
dc.contributor.author | Gisbert, Javier P. | - |
dc.date.accessioned | 2022-10-03T09:57:37Z | - |
dc.date.available | 2022-10-03T09:57:37Z | - |
dc.date.issued | 2022-08-29 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | http://hdl.handle.net/2445/189565 | - |
dc.description.abstract | The stool antigen test (SAT) represents an attractive alternative for detection of Helicobacter pylori. The aim of this study was to assess the accuracy of a new SAT, the automated LIAISON(R) Meridian H. pylori SA based on monoclonal antibodies, compared to the defined gold standard C-13-urea breath test (UBT). This prospective multicentre study (nine Spanish centres) enrolled patients >= 18 years of age with clinical indication to perform UBT for the initial diagnosis and for confirmation of bacterial eradication. Two UBT methods were used: mass spectrometry (MS) including citric acid (CA) or infrared spectrophotometry (IRS) without CA. Overall, 307 patients (145 naive, 162 with confirmation of eradication) were analysed. Using recommended cut-off values (negative SAT < 0.90, positive >= 1.10) the sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 67%, 97%, 86%, 92% and 91%, respectively, obtaining an area under the receiver operating characteristic (ROC) curve (AUC) of 0.85. Twenty-eight patients, including seven false positives and 21 false negatives, presented a discordant result between SAT and UBT. Among the 21 false negatives, four of six tested with MS and 11 of 15 tested with IRS presented a borderline UBT delta value. In 25 discordant samples, PCR targeting H. pylori DNA was performed to re-assess positivity and SAT accuracy was re-analysed: sensitivity, specificity, positive predictive value, negative predictive value, accuracy and AUC were 94%, 97%, 86%, 99%, 97% and 0.96, respectively. The new LIAISON(R) Meridian H. pylori SA SAT showed a good accuracy for diagnosis of H. pylori infection. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/jcm11175077 | - |
dc.relation.ispartof | Journal of Clinical Medicine, 2022, vol. 11, num. 17, p. 5077 | - |
dc.relation.uri | https://doi.org/10.3390/jcm11175077 | - |
dc.rights | cc by (c) Resina, Elena et al., 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Helicobacter pylori | - |
dc.subject.classification | Diagnòstic | - |
dc.subject.other | Helicobacter pylori | - |
dc.subject.other | Diagnosis | - |
dc.title | Evaluation of a New Monoclonal Chemiluminescent Immunoassay Stool Antigen Test for the Diagnosis of Helicobacter pylori Infection: A Spanish Multicentre Study | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-09-29T10:22:47Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 36079007 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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jcm-11-05077-v3.pdf | 720.48 kB | Adobe PDF | View/Open |
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