Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/189567
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | García Mejido, José A. | - |
dc.contributor.author | Sánchez Sevilla, Miguel | - |
dc.contributor.author | González Martínez, Jesús | - |
dc.contributor.author | Fernández Palacín, Ana | - |
dc.contributor.author | Sainz Bueno, José A. | - |
dc.date.accessioned | 2022-10-03T10:28:04Z | - |
dc.date.available | 2022-10-03T10:28:04Z | - |
dc.date.issued | 2022-07-15 | - |
dc.identifier.issn | 35944438 | - |
dc.identifier.issn | 2444-054X | - |
dc.identifier.uri | http://hdl.handle.net/2445/189567 | - |
dc.description.abstract | Introduction: To determine whether clinicopathological characteristics can improve the prediction of metastasis to nonsentinel lymph nodes (NSLNs) over the use of only mRNA copy number in sentinel lymph node (SLN) biopsies. Methods: This was a retrospective, observational study that included a total of 824 patients with T1-3 breast cancer who had clinically negative, ultrasound-negative axilla without evidence of metastasis and who underwent one-step nucleic acid amplification in SLN biop-sies. Results: 118 required a complete axillary lymph node dissection (ALNhD). About 35.6% (42/118) had metastases to a NSLN, and 64.4% (76/118) had no metastasis to a NSLN. The ROC curve of the total tumor load (TTL) presented an area under the curve (AUC) of 0.651 (95%; CI: 0.552-0.751). The 7294 copies of CK19 mRNA were established as the optimal cutoff point, with sensitivity: 93%, specificity: 63%, positive predictive value: 44%, and negative predictive value: 91%. By as-sociating the clinicopathological parameters (multicentricity, pooled immunohistochemistry [IHC], and progesterone receptors), the AUC went up to 0.752 (95% CI: 0.663-0.841). Conclusions: Clinicopathological factors should be considered together with the total CK19 mRNA copy number (the TTL) of the SLNs to improve the predictive capacity of metastatic involvement of the NSLNs. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Publicidad Permanyer, SLU | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.24875/CIRU.21000148 | - |
dc.relation.ispartof | Cirugía y Cirujanos, 2022, vol. 90, issue. 4 | - |
dc.relation.uri | https://doi.org/10.24875/CIRU.21000148 | - |
dc.rights | cc by-nc-nd (c) Academia Mexicana de Cirugía, 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.classification | Ganglis sentinelles | - |
dc.subject.other | Breast cancer | - |
dc.subject.other | Sentinel lymph nodes | - |
dc.title | ¿Pueden los factores clínicopatológicos mejorar la predicción de metástasis en ganglios linfáticos no centinelas en pacientes con cáncer de mama? | - |
dc.type | info:eu-repo/semantics/article | - |
dc.date.updated | 2022-08-18T11:33:58Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
circir_22_90_4_473-480.pdf | 357.21 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License