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http://hdl.handle.net/2445/189684
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DC Field | Value | Language |
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dc.contributor.author | Companys Alemany, Júlia | - |
dc.contributor.author | Roig-Soriano, Joan | - |
dc.contributor.author | Turcu, Andreea L. | - |
dc.contributor.author | Chillón, Miguel | - |
dc.contributor.author | Vázquez Cruz, Santiago | - |
dc.contributor.author | Pallàs i Llibería, Mercè, 1964- | - |
dc.contributor.author | Griñán Ferré, Christian | - |
dc.date.accessioned | 2022-10-06T10:26:17Z | - |
dc.date.available | 2023-10-05T05:10:27Z | - |
dc.date.issued | 2022-10-05 | - |
dc.identifier.issn | 0959-4965 | - |
dc.identifier.uri | http://hdl.handle.net/2445/189684 | - |
dc.description.abstract | N-methyl-D-aspartate (NMDA) receptor antagonists mediate adult neurogenic effects. Here, the neurogenic effect of a new NMDA receptor antagonist endowed with neuroprotective effects in Alzheimer's disease mice model. Nine-month-old senescence-accelerated mouse prone 8 (SAMP8) with UB-ALT-EV were orally treated. 5-Bromo-2-deoxyuridine (BrdU) (50 mg/kg) was 3× injected I.P. every 2 h. After 28 days of treatment, SAMP8-treated group improved working memory. Moreover, the number of BrdU+ cells and DCX+ cells in the SAMP8 dentate gyrus (DG) was significantly increased. GFAP+ cells were not affected by treatment. Together, these results provided evidence that UB-ALT-EV promotes the survival and proliferation of neural progenitor cells in the aged SAMP8 hippocampus. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Lippincott, Williams & Wilkins | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1097/WNR.0000000000001825 | - |
dc.relation.ispartof | NeuroReport, 2022, vol. 33, num. 4, p. 623-628 | - |
dc.relation.uri | https://doi.org/10.1097/WNR.0000000000001825 | - |
dc.rights | (c) Lippincott, Williams & Wilkins, 2022 | - |
dc.source | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) | - |
dc.subject.classification | Hipocamp (Cervell) | - |
dc.subject.classification | Malalties neurodegeneratives | - |
dc.subject.classification | Envelliment | - |
dc.subject.other | Hippocampus (Brain) | - |
dc.subject.other | Neurodegenerative Diseases | - |
dc.subject.other | Aging | - |
dc.title | Optimized N-methyl-D-aspartate receptor antagonist exhibits hippocampal proneurogenic effects in aged senescence-accelerated mouse prone 8 mice | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 724612 | - |
dc.date.updated | 2022-10-06T10:26:18Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica) |
Files in This Item:
File | Description | Size | Format | |
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724612.pdf | 2.28 MB | Adobe PDF | View/Open |
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