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Title: Fatal airway disease in an adult with chronic graft-versus-host disease
Author: Roca Torrent, Josep
Grañena Batista, Alberto
Rodríguez-Roisin, Robert
Alvarez, P.
Agusti-Vidal, A. (Albert)
Rozman, Ciril, 1929-
Keywords: Malalties del pulmó
Trasplantament d'òrgans
Complicacions quirúrgiques
Pulmonary diseases
Transplantation of organs
Complications of surgery
Issue Date: 1982
Publisher: BMJ Publishing Group
Abstract: Chronic graft-versus-host disease (GVHD) is a syndrome of disordered immunity in which a variety of opportunistic respiratory infections have been documented. Restrictive pulmonary disease without advanced fibrotic changes has been also known to occur; obstructive lower airways disease related to chronic GVHD has apparently not been referred to. We report a patient with chronic GVHD and irreversible airways obstruction who died in respiratory failure caused by generalised bronchiolar damage progressing over a few months. Lung function studies showed severe airflow limitation and a leftward shift in the pressure-volume curve indicating a loss of elastic recoil pressure. Postmortem pulmonary lesions were consistent with a necrotising obliterative bron chiolitis. Our purpose is to describe this unusual complication not previously reported in chronic GVHD and discuss the pulmonary mechanics.
Note: Reproducció del document publicat a:
It is part of: Thorax, 1982, vol. 37, p. 77-78
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ISSN: 0040-6376
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (Ciències Clíniques)

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