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http://hdl.handle.net/2445/189851
Title: | Fatal airway disease in an adult with chronic graft-versus-host disease |
Author: | Roca Torrent, Josep Grañena Batista, Alberto Rodríguez-Roisin, Robert Alvarez, P. Agusti-Vidal, A. (Albert) Rozman, Ciril, 1929- |
Keywords: | Malalties del pulmó Trasplantament d'òrgans Complicacions quirúrgiques Pulmonary diseases Transplantation of organs Complications of surgery |
Issue Date: | 1982 |
Publisher: | BMJ Publishing Group |
Abstract: | Chronic graft-versus-host disease (GVHD) is a syndrome of disordered immunity in which a variety of opportunistic respiratory infections have been documented. Restrictive pulmonary disease without advanced fibrotic changes has been also known to occur; obstructive lower airways disease related to chronic GVHD has apparently not been referred to. We report a patient with chronic GVHD and irreversible airways obstruction who died in respiratory failure caused by generalised bronchiolar damage progressing over a few months. Lung function studies showed severe airflow limitation and a leftward shift in the pressure-volume curve indicating a loss of elastic recoil pressure. Postmortem pulmonary lesions were consistent with a necrotising obliterative bron chiolitis. Our purpose is to describe this unusual complication not previously reported in chronic GVHD and discuss the pulmonary mechanics. |
Note: | Reproducció del document publicat a: https://doi.org/10.1136/thx.37.1.77 |
It is part of: | Thorax, 1982, vol. 37, p. 77-78 |
URI: | http://hdl.handle.net/2445/189851 |
Related resource: | https://doi.org/10.1136/thx.37.1.77 |
ISSN: | 0040-6376 |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (Ciències Clíniques) |
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File | Description | Size | Format | |
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013714.pdf | 446.28 kB | Adobe PDF | View/Open |
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