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http://hdl.handle.net/2445/189870
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DC Field | Value | Language |
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dc.contributor.author | Han, Bing | - |
dc.contributor.author | Molins López-Rodó, Laureano | - |
dc.contributor.author | He, Yangyi | - |
dc.contributor.author | Viñolas Segarra, Núria | - |
dc.contributor.author | Sánchez Lorente, David | - |
dc.contributor.author | Boada, Marc | - |
dc.contributor.author | Guirao, Ángela | - |
dc.contributor.author | Díaz Sánchez, Tania | - |
dc.contributor.author | Martinez, Daniel | - |
dc.contributor.author | Ramirez, José | - |
dc.contributor.author | Moisés, Jorge | - |
dc.contributor.author | Acosta Plasencia, Melissa | - |
dc.contributor.author | Monzó Planella, Mariano | - |
dc.contributor.author | Marrades Sicart, Ramon Ma. | - |
dc.contributor.author | Navarro Ponz, Alfons | - |
dc.date.accessioned | 2022-10-13T14:49:38Z | - |
dc.date.available | 2022-10-13T14:49:38Z | - |
dc.date.issued | 2022-06-27 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/2445/189870 | - |
dc.description.abstract | In resected non-small cell lung cancer (NSCLC), post-surgical recurrence occurs in around 40% of patients, highlighting the necessity to identify relapse biomarkers. An analysis of the extracellular vesicle (EV) cargo from a pulmonary tumor-draining vein (TDV) can grant biomarker identification. We studied the pulmonary TDV EV-miRNAome to identify relapse biomarkers in a two-phase study (screening and validation). In the screening phase, a 17-miRNA relapse signature was identified in 18 selected patients by small RNAseq. The most expressed miRNA from the signature (EV-miR-203a-3p) was chosen for further validation. Pulmonary TDV EV-miR-203a-3p was studied by qRT-PCR in a validation cohort of 70 patients, where it was found to be upregulated in relapsed patients (p = 0.0194) and in patients with cancer spread to nearby lymph nodes (N+ patients) (p = 0.0396). The ROC curve analysis showed that TDV EV-miR-203a-3p was able to predict relapses with a sensitivity of 88% (AUC: 0.67; p = 0.022). Moreover, patients with high TDV EV-miR-203a-3p had a shorter time to relapse than patients with low levels (43.6 vs. 97.6 months; p = 0.00703). The multivariate analysis showed that EV-miR-203a-3p was an independent, predictive and prognostic post-surgical relapse biomarker. In conclusion, pulmonary TDV EV-miR-203a-3p is a promising new relapse biomarker for resected NSCLC patients. | - |
dc.format.extent | 20 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/ijms23137138 | - |
dc.relation.ispartof | International Journal of Molecular Sciences, 2022, vol. 23, num. 13, p. 7138 | - |
dc.relation.uri | https://doi.org/10.3390/ijms23137138 | - |
dc.rights | cc-by (c) Han, Bing et al., 2022 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Marcadors tumorals | - |
dc.subject.classification | Càncer de pulmó | - |
dc.subject.classification | Micro RNAs | - |
dc.subject.other | Tumor markers | - |
dc.subject.other | Lung cancer | - |
dc.subject.other | MicroRNAs | - |
dc.title | Characterization of the MicroRNA Cargo of Extracellular Vesicles Isolated from a Pulmonary Tumor-Draining Vein Identifies miR-203a-3p as a Relapse Biomarker for Resected Non-Small Cell Lung Cancer. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 725678 | - |
dc.date.updated | 2022-10-13T14:49:39Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 35806142 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
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725678.pdf | 2.31 MB | Adobe PDF | View/Open |
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