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http://hdl.handle.net/2445/189979
Title: | A microRNA cluster controls fat cell differentiation and adipose tissue expansion by regulating SNCG |
Author: | Rodriguez-Barrueco, Ruth Latorre, Jessica Devis Jauregui, Laura Lluch, Aina Bonifaci Cano, Núria Llobet, Francisco J. Olivan Riera, Mireia Coll-Iglesias, Laura Gassner, Katja Davis, Meredith L. Moreno-Navarrete, José María Castells-Nobau, Anna Plata Peña, Laura Dalmau-Pastor, Miki Höring, Marcus Liebisch, Gerhard Olkkonen, Vesa M. Arnoriaga Rodríguez, María Ricart, Wifredo Fernández-Real, José M. Silva, José M. Ortega, Francisco J. Llobet-Navas, David |
Keywords: | Teixit adipós Obesitat Experimentació animal Diferenciació cel·lular Adipose tissues Obesity Animal experimentation Cell diferentiation |
Issue Date: | 1-Dec-2021 |
Publisher: | Wiley-VCH Verlag |
Abstract: | The H19X-encoded miR-424(322)/503 cluster regulates multiple cellular functions. Here, it is reported for the first time that it is also a critical linchpin of fat mass expansion. Deletion of this miRNA cluster in mice results in obesity, while increasing the pool of early adipocyte progenitors and hypertrophied adipocytes. Complementary loss and gain of function experiments and RNA sequencing demonstrate that miR-424(322)/503 regulates a conserved genetic program involved in the differentiation and commitment of white adipocytes. Mechanistically, it is demonstrated that miR-424(322)/503 targets γ-Synuclein (SNCG), a factor that mediates this program rearrangement by controlling metabolic functions in fat cells, allowing adipocyte differentiation and adipose tissue enlargement. Accordingly, diminished miR-424(322) in mice and obese humans co-segregate with increased SNCG in fat and peripheral blood as mutually exclusive features of obesity, being normalized upon weight loss. The data unveil a previously unknown regulatory mechanism of fat mass expansion tightly controlled by the miR-424(322)/503 through SNCG. |
Note: | Reproducció del document publicat a: https://doi.org/10.1002/advs.202104759 |
It is part of: | Advanced Science, 2021, vol. 9, num. 4 |
URI: | http://hdl.handle.net/2445/189979 |
Related resource: | https://doi.org/10.1002/advs.202104759 |
ISSN: | 2198-3844 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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