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Title: | Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane−Polyurea Hybrid Nanocarrier |
Author: | Bonelli Blasco, Joaquin Daniel Ortega Forte, Enrique Rovira, Anna Bosch Marimon, Manel Torres, Oriol Cuscó Marigó, Cristina Rocas Sorolla, Josep Ruiz, José Marchán Sancho, Vicente |
Keywords: | Cumarines Polímers Tumors Coumarins Polymers Tumors |
Issue Date: | 13-Jun-2022 |
Publisher: | American Chemical Society |
Abstract: | Integration of photosensitizers (PSs) within nanoscale delivery systems offers great potential for overcoming some of the 'Achiles' heels' of photodynamic therapy (PDT). Herein, we have encapsulated a mitochondria-targeted coumarin PS into amphoteric polyurethane-polyurea hybrid nanocapsules (NCs) with the aim of developing novel nanoPDT agents. The synthesis of coumarin-loaded NCs involved the nanoemulsification of a suitable prepolymer in the presence of a PS without needing external surfactants, and the resulting small nanoparticles showed improved photostability compared with the free compound. Nanoencapsulation reduced dark cytotoxicity of the coumarin PS and significantly improved in vitro photoactivity with red light toward cancer cells, which resulted in higher phototherapeutic indexes compared to free PS. Importantly, this nanoformulation impaired tumoral growth of clinically relevant three-dimensional multicellular tumor spheroids. Mitochondrial photodamage along with reactive oxygen species (ROS) photogeneration was found to trigger autophagy and apoptotic cell death of cancer cells. |
Note: | Reproducció del document publicat a: https://doi.org/10.1021/acs.biomac.2c00361 |
It is part of: | Biomacromolecules, 2022, vol. 23, num. 7, p. 2900-2913 |
URI: | http://hdl.handle.net/2445/190222 |
Related resource: | https://doi.org/10.1021/acs.biomac.2c00361 |
ISSN: | 1525-7797 |
Appears in Collections: | Articles publicats en revistes (Institut de Biomedicina (IBUB)) Articles publicats en revistes (Química Inorgànica i Orgànica) |
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