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Title: | Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue |
Author: | González Franquesa, Alba Gama-Perez, Pau Kulis, Marta Szczepanowska, K. Dahdah, Norma Moreno-Gomez, Sonia Latorre Pellicer, Ana Fernández Ruiz, Rebeca Aguilar-Mogas, Antoni Hoffman, Anne Monelli, Erika Samino Gené, Sara Miró-Blanch, Joan Oemer, Gregor Duran, Xavier Sanchez-Rebordelo, Estrella Schneeberger, Marc Obach, Merce Montane, Joel Castellano, Giancarlo Chapaprieta, Vicente Sun, Wenfei Navarro, Lourdes Prieto, Ignacio Castaño, Carlos Novials, Anna Gomis, Ramon, 1946- Monsalve, Maria Claret i Carles, Marc Graupera i Garcia-Milà, Mariona Soria, Guadalupe Wolfrum, Christian Vendrell, Joan Fernández-Veledo, Sonia Enriquez, Jose Antonio Carracedo Álvarez, Ángel Perales Losa, Carlos Nogueiras, Rubén Herrero, Laura Trifunovic, Aleksandra Keller, Markus A Yanes, Oscar Sales-Pardo, Marta Guimerà, Roger Blüher, Matthias Martín-Subero, José Ignacio Garcia Roves, Pablo M. |
Keywords: | Resistència a la insulina Obesitat Teixit adipós Mitocondris Insulin resistance Obesity Adipose tissues Mitochondria |
Issue Date: | 1-Aug-2022 |
Publisher: | Elsevier B.V. |
Abstract: | Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention. Although most obesity and overnutrition-related pathological features were successfully reverted, we observed a high degree of metabolic dysfunction in visceral white adipose tissue, characterized by abnormal mitochondrial morphology and functionality. Despite two sequential therapeutic interventions and an apparent global healthy phenotype, obesity triggered a cascade of events in visceral adipose tissue progressing from mitochondrial metabolic and proteostatic alterations to widespread cellular stress, which compromises its biosynthetic and recycling capacity. In humans, weight loss after bariatric surgery showed a transcriptional signature in visceral adipose tissue similar to our mouse model of obesity reversion. Overall, our data indicate that obesity prompts a lasting metabolic fingerprint that leads to a progressive breakdown of metabolic plasticity in visceral adipose tissue. |
Note: | Document publicat a: https://doi.org/10.1016/j.redox.2022.102353 |
It is part of: | Redox Biology, 2022, vol. 54 |
URI: | http://hdl.handle.net/2445/190251 |
Related resource: | https://doi.org/10.1016/j.redox.2022.102353 |
ISSN: | 2213-2317 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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