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Title: Remission of obesity and insulin resistance is not sufficient to restore mitochondrial homeostasis in visceral adipose tissue
Author: González Franquesa, Alba
Gama-Perez, Pau
Kulis, Marta
Szczepanowska, K.
Dahdah, Norma
Moreno-Gomez, Sonia
Latorre Pellicer, Ana
Fernández Ruiz, Rebeca
Aguilar-Mogas, Antoni
Hoffman, Anne
Monelli, Erika
Samino Gené, Sara
Miró-Blanch, Joan
Oemer, Gregor
Duran, Xavier
Sanchez-Rebordelo, Estrella
Schneeberger, Marc
Obach, Merce
Montane, Joel
Castellano, Giancarlo
Chapaprieta, Vicente
Sun, Wenfei
Navarro, Lourdes
Prieto, Ignacio
Castaño, Carlos
Novials, Anna
Gomis, Ramon, 1946-
Monsalve, Maria
Claret i Carles, Marc
Graupera i Garcia-Milà, Mariona
Soria, Guadalupe
Wolfrum, Christian
Vendrell, Joan
Fernández-Veledo, Sonia
Enriquez, Jose Antonio
Carracedo Álvarez, Ángel
Perales Losa, Carlos
Nogueiras, Rubén
Herrero, Laura
Trifunovic, Aleksandra
Keller, Markus A
Yanes, Oscar
Sales-Pardo, Marta
Guimerà, Roger
Blüher, Matthias
Martín-Subero, José Ignacio
Garcia Roves, Pablo M.
Keywords: Resistència a la insulina
Teixit adipós
Insulin resistance
Adipose tissues
Issue Date: 1-Aug-2022
Publisher: Elsevier B.V.
Abstract: Metabolic plasticity is the ability of a biological system to adapt its metabolic phenotype to different environmental stressors. We used a whole-body and tissue-specific phenotypic, functional, proteomic, metabolomic and transcriptomic approach to systematically assess metabolic plasticity in diet-induced obese mice after a combined nutritional and exercise intervention. Although most obesity and overnutrition-related pathological features were successfully reverted, we observed a high degree of metabolic dysfunction in visceral white adipose tissue, characterized by abnormal mitochondrial morphology and functionality. Despite two sequential therapeutic interventions and an apparent global healthy phenotype, obesity triggered a cascade of events in visceral adipose tissue progressing from mitochondrial metabolic and proteostatic alterations to widespread cellular stress, which compromises its biosynthetic and recycling capacity. In humans, weight loss after bariatric surgery showed a transcriptional signature in visceral adipose tissue similar to our mouse model of obesity reversion. Overall, our data indicate that obesity prompts a lasting metabolic fingerprint that leads to a progressive breakdown of metabolic plasticity in visceral adipose tissue.
Note: Document publicat a:
It is part of: Redox Biology, 2022, vol. 54
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ISSN: 2213-2317
Appears in Collections:Publicacions de projectes de recerca finançats per la UE
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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