Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/190410
Title: | Circulating carotenoids are associated with favorable lipid and fatty acid profiles in an older population at high cardiovascular risk |
Author: | Marhuenda-Muñoz, María Domínguez López, Inés Langohr, Klaus Tresserra i Rimbau, Anna Martínez-González, Miguel Ángel, 1957- Salas Salvadó, Jordi Corella Piquer, Dolores Zomeño Fajardo, María Dolores Martínez, J. Alfredo, 1957- Alonso Gómez, Ángel M. Wärnberg, Julia Vioque, Jesús Romaguera, Dora López Miranda, José Estruch Riba, Ramon Tinahones, Francisco J. Lapetra, José Serra Majem, Lluís Bueno Cavanillas, Aurora Tur, Josep Antoni Martín Sánchez, Vicente Pintó Sala, Xavier Delgado Rodriguez, Miguel Matía Martín, Pilar Vidal i Cortada, Josep Vázquez, Clotilde Daimiel, Lidia Ros Rahola, Emilio Toledo Atucha, Estefanía Fernández de la Puente, María Barragán, Rocío Fitó Colomer, Montserrat Tojal Sierra, Lucas Gómez Gracia, Enrique Zazo, Juan Manuel Morey, Marga García Ríos, Antonio Casas Rodríguez, Rosa M. Gómez Pérez, Ana María Santos Lozano, Jose Manuel Vázquez Ruiz, Zenaida Atzeni, Alessandro Asensio, Eva M. Gili Riu, M Mar Bullón Vela, Vanessa Moreno Rodriguez, Anai Lecea Juárez, Oscar Babio, Nancy Peñas Lopez, Francesca Gómez Melis, Guadalupe Lamuela Raventós, Rosa Ma. |
Keywords: | Malalties cardiovasculars Carotenoides Plasma sanguini Cromatografia de líquids Espectrometria de masses Cuina mediterrània Cardiovascular diseases Carotenoids Blood plasma Liquid chromatography Mass spectrometry Mediterranean cooking |
Issue Date: | 29-Sep-2022 |
Publisher: | Frontiers Media |
Abstract: | Carotenoid intake has been reported to be associated with improved cardiovascular health, but there is little information on actual plasma concentrations of these compounds as biomarkers of cardiometabolic risk. The objective was to investigate the association between circulating plasma carotenoids and different cardiometabolic risk factors and the plasma fatty acid profile. This is a cross-sectional evaluation of baseline data conducted in a subcohort (106 women and 124 men) of an ongoing multi-factorial lifestyle trial for primary cardiovascular prevention. Plasma concentrations of carotenoids were quantified by liquid chromatography coupled to mass spectrometry. The associations between carotenoid concentrations and cardiometabolic risk factors were assessed using regression models adapted for interval-censored variables. Carotenoid concentrations were cross-sectionally inversely associated with serum triglyceride concentrations [-2.79 mg/dl (95% CI: -4.25, -1.34) and -5.15 mg/dl (95% CI: -7.38, -2.93), p-values = 0.0002 and <0.00001 in women and men, respectively], lower levels of plasma saturated fatty acids [-0.09% (95% CI: -0.14, -0.03) and -0.15 % (95% CI: -0.23, -0.08), p-values = 0.001 and 0.0001 in women and men, respectively], and higher levels of plasma polyunsaturated fatty acids [(0.12 % (95% CI: -0.01, 0.25) and 0.39 % (95% CI: 0.19, 0.59), p-values = 0.065 and 0.0001 in women and men, respectively] in the whole population. Plasma carotenoid concentrations were also associated with higher plasma HDL-cholesterol in women [0.47 mg/dl (95% CI: 0.23, 0.72), p-value: 0.0002], and lower fasting plasma glucose in men [-1.35 mg/dl (95% CI: -2.12, -0.59), p-value: 0.001]. Keywords: Mediterranean diet; PREDIMED-plus study; cardiovascular health; liquid chromatography; mass spectrometry; plasma carotenoids. |
Note: | Reproducció del document publicat a: https://doi.org/10.3389/fnut.2022.967967.eCollection |
It is part of: | Frontiers In Nutrition, 2022, vol. 9, p. 967967 |
URI: | http://hdl.handle.net/2445/190410 |
Related resource: | https://doi.org/10.3389/fnut.2022.967967.eCollection |
ISSN: | 2296-861X |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
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