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Title: Does Consumption of Ultra-Processed Foods Matter for Liver Health? Prospective Analysis among Older Adults with Metabolic Syndrome
Author: Konieczna, Jadwiga
Fiol Sala, Miguel
Colom, Antoni
Martínez-González, Miguel Ángel, 1957-
Salas Salvadó, Jordi
Corella Piquer, Dolores
Soria Florido, María Trinidad
Martínez, J. Alfredo, 1957-
Alonso Gómez, Ángel M.
Wärnberg, Julia
Vioque, Jesús
López Miranda, José
Estruch Riba, Ramon
Bernal López, M. Rosa
Lapetra, José
Serra Majem, Lluís
Bueno Cavanillas, Aurora
Tur, Josep Antoni
Martín Sánchez, Vicente
Pintó Sala, Xavier
Gaforio, José J.
Matía Martín, Pilar
Vidal i Cortada, Josep
Vázquez, Clotilde
Daimiel, Lidia
Ros Rahola, Emilio
Bes Rastrollo, Maira
Pascual, Maria
Sorlí, José V.
Goday Arnó, Albert
Zulet, M. Ángeles
Moreno Rodriguez, Anai
Carmona González, Francisco Jesús
Valls Enguix, Rafael
Janer, Juana M.
Garcia-Rios, Antonio
Casas Rodríguez, Rosa M.
Gómez Pérez, Ana María
Santos Lozano, Jose Manuel
Basterra Gortari, Francisco Javier
Martínez, María Ángeles
Ortega Azorín, Carolina
Bayó i Llibre, Joan
Abete, Itziar
Salaverria Lete, Itziar
Ruiz Canela, Miguel
Babio, Nancy
Carres, Lourdes
Romaguera, Dora
Keywords: Malalties del fetge
Síndrome metabòlica
Aliments artificials
Liver diseases
Metabolic syndrome
Artificial foods
Issue Date: 5-Oct-2022
Publisher: MDPI
Abstract: Non-alcoholic fatty liver disease (NAFLD) includes a spectrum of liver alterations that can result in severe disease and even death. Consumption of ultra-processed foods (UPF) has been associated with obesity and related comorbidities. However, the link between UPF and NAFLD has not been sufficiently assessed. We aimed to investigate the prospective association between UPF consumption and liver health biomarkers. Methods: We followed for 1 year 5867 older participants with overweight/obesity and metabolic syndrome (MetS) from the PREDIMED-Plus trial. A validated 143-item semi-quantitative food frequency questionnaire was used to evaluate consumption of UPF at baseline, 6, and 12 months. The degree of processing for foods and beverages (g/day) was established according to the NOVA classification system. The non-invasive fatty liver index (FLI) and hepatic steatosis index (HSI) were used to evaluate liver health at three points in time. The associations between changes in UPF consumption (percentage of total daily dietary intake (g)) and liver biomarkers were assessed using mixed-effects linear models with repeated measurements. Results: In this cohort, UPF consumption at baseline was 8.19% (SD 6.95%) of total daily dietary intake in grams. In multivariable models, each 10% daily increment in UPF consumption in 1 year was associated with significantly greater FLI (β 1.60 points, 95% CI 1.24;1.96 points) and HSI (0.43, 0.29; 0.57) scores (all p-values < 0.001). These associations persisted statistically significant after adjusting for potential dietary confounders and NAFLD risk factors. Conclusions: A higher UPF consumption was associated with higher levels of NAFLD-related biomarkers in older adults with overweight/obesity and MetS.
Note: Reproducció del document publicat a:
It is part of: Nutrients, 2022, vol. 14, num. 19, p. 4142
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ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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