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http://hdl.handle.net/2445/190743
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DC Field | Value | Language |
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dc.contributor.author | Meneghini, Maria | - |
dc.contributor.author | Perona, Anna | - |
dc.contributor.author | Crespo Fernández, Elena | - |
dc.contributor.author | Bemelman, Frederike | - |
dc.contributor.author | Reinke, Petra | - |
dc.contributor.author | Viklicky, Ondrej | - |
dc.contributor.author | Giral, Magali | - |
dc.contributor.author | Palou, Eduard | - |
dc.contributor.author | Torija, Alba | - |
dc.contributor.author | Donadeu, Laura | - |
dc.contributor.author | Melilli, Edoardo | - |
dc.contributor.author | Zuñiga, Jose | - |
dc.contributor.author | Sefrin, Anett | - |
dc.contributor.author | Lachmann, Nils | - |
dc.contributor.author | Hu, Liu | - |
dc.contributor.author | Hruba, Petra | - |
dc.contributor.author | Guillot Gueguen, Cécile | - |
dc.contributor.author | Brouard, Sophie | - |
dc.contributor.author | Grinyó Boira, Josep M. | - |
dc.contributor.author | Bestard Matamoros, Oriol | - |
dc.date.accessioned | 2022-11-14T11:24:43Z | - |
dc.date.available | 2022-11-14T11:24:43Z | - |
dc.date.issued | 2022-09-29 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | http://hdl.handle.net/2445/190743 | - |
dc.description.abstract | Complete and high-resolution (HR) HLA typing improves the accurate assessment of donor-recipient compatibility and pre-transplant donor-specific antibodies (DSA). However, the value of this information to identify de novo immune-mediated graft events and its impact on outcomes has not been assessed. In 241 donor/recipient kidney transplant pairs, DNA samples were re-evaluated for six-locus (A/B/C/DRB1/DQB1+A1/DPB1) HR HLA typing. De novo anti-HLA antibodies were assessed using solid-phase assays, and dnDSA were classified either (1) as per current clinical practice according to three-locus (A/B/DRB1) low-resolution (LR) typing, estimating donor HLA-C/DQ typing with frequency tables, or (2) according to complete six-locus HR typing. The impact on graft outcomes was compared between groups. According to LR HLA typing, 36 (15%) patients developed dnDSA (LR_dnDSA+). Twenty-nine out of 36 (80%) were confirmed to have dnDSA by HR typing (LR_dnDSA+/HR_dnDSA+), whereas 7 (20%) did not (LR_dnDSA+/HR_dnDSA-). Out of 49 LR_dnDSA specificities, 34 (69%) were confirmed by HR typing whereas 15 (31%) LR specificities were not confirmed. LR_dnDSA+/HR_dnDSA+ patients were at higher risk of ABMR as compared to dnDSA- and LR_dnDSA+/HR_dnDSA- (logRank < 0.001), and higher risk of death-censored graft loss (logRank = 0.001). Both LR_dnDSA+ (HR: 3.51, 95% CI = 1.25-9.85) and LR_dnDSA+/HR_dnDSA+ (HR: 4.09, 95% CI = 1.45-11.54), but not LR_dnDSA+/HR_dnDSA- independently predicted graft loss. The implementation of HR HLA typing improves the characterization of biologically relevant de novo anti-HLA DSA and discriminates patients with poorer graft outcomes. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media SA | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2022.924825 | - |
dc.relation.ispartof | Frontiers in Immunology, 2022, vol. 13 | - |
dc.relation.uri | https://doi.org/10.3389/fimmu.2022.924825 | - |
dc.rights | cc by (c) Meneghini, Maria et al., 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Trasplantament renal | - |
dc.subject.classification | Rebuig (Biologia) | - |
dc.subject.other | Kidney transplantation | - |
dc.subject.other | Graft rejection | - |
dc.title | On the clinical relevance of using complete high-resolution HLA typing for an accurate interpretation of posttransplant immune-mediated graft outcomes | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-11-04T10:58:27Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/305147/EU//BIO-DRIM | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 36248818 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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fimmu-13-924825.pdf | 1.3 MB | Adobe PDF | View/Open |
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