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Title: Stigmatization is common in patients with non-alcoholic fatty liver disease and correlates with quality of life
Author: Carol, Marta
Pérez-Guasch, Martina
Solà, Elsa
Cervera, Marta
Martínez, Sara
Juanola, Adrià
Ma, Ann T.
Avitabile, Emma
Napoleone, Laura
Pose, Elisa
Graupera, Isabel
Honrubia, Maria
Korenjak, Marko
Torres, Ferran
Ginès, Pere
Fabrellas i Padrès, Núria
Keywords: Cirrosi hepàtica
Malalties del fetge
Qualitat de vida
Hepatic cirrhosis
Liver diseases
Quality of life
Issue Date: 1-May-2022
Publisher: Public Library of Science (PLoS)
Abstract: Background and aims: Stigmatization is a well-documented problem of some diseases. Perceived stigma is common in alcohol-related liver disease and hepatitis C, but little information exists on stigma in patients with non-alcoholic fatty liver disease (NAFLD). Aim of the study was to investigate frequency and characteristics of perceived stigma among patients with NAFLD. Methods: One-hundred and ninety-seven patients seen at the liver clinic were included: a study group of 144 patients with NAFLD, 50 with cirrhosis (34 compensated, 16 decompensated), and a control group of 53 patients with alcohol-related cirrhosis. Demographic, clinical, and laboratory data were collected. Quality-of-life was assessed by chronic liver disease questionnaire (CLDQ). Perceived stigma was assessed using a specific questionnaire for patients with liver diseases categorized in 4 domains: stereotypes, discrimination, shame, and social isolation. Results: Perceived stigma was common in patients with NAFLD (99 patients, 69%) and affected all 4 domains assessed. The frequency was slightly higher, yet not significant, in patients with NAFLD cirrhosis vs those without (72% vs 67%, respectively; p = 0.576). In patients without cirrhosis perceived stigma was unrelated to stage of disease, since frequency was similar in patients with no or mild fibrosis compared to those with moderate/severe fibrosis (66% vs 68%, respectively). There were no differences in perceived stigma between patients with compensated cirrhosis and these with decompensated cirrhosis. Among patients with cirrhosis, stigmatization was more common in alcohol-related vs NAFLD-cirrhosis, yet differences were only significant in two domains. In patients with NAFLD, perceived stigma correlated with poor quality-of-life, but not with demographic or clinical variables. Conclusions: Perceived stigmatization is common among patients with NAFLD independently of disease stage, is associated with impaired quality-of-life, and may be responsible for stereotypes, discrimination, shame, and social isolation, which may affect human and social rights of affected patients.
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It is part of: PLoS One, 2022, vol. 17, p. e0265153
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)

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