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Title: Could alpha-Synuclein Amyloid-like aggregates trigger a prionic neuronal invasion?
Author: Espargaró Colomé, Alba
Busquets i Viñas, Ma. Antonia
Estelrich i Latràs, Joan
Sabaté Lagunas, Raimon
Keywords: Amiloïdosi
Malaltia de Parkinson
Parkinson's disease
Issue Date: 2015
Publisher: Hindawi
Abstract: Parkinson's disease (PD), a progressive neurodegenerative disease primarily affecting voluntary and controlled movement, is characterized by abnormal accumulations of 𝛼-synuclein (𝛼-syn) in intraneuronal Lewy bodies. In the last years, the increased number of evidences from both the in vitro and in vivo studies has shown the ability of 𝛼-syn to misfold in amyloid conformations and to spread via neuron-to-neuron transmission, suggesting a prion-like behaviour. However, in contrast to prion protein (PrP), 𝛼-syn transmission is far from neuronal invasion. The high neuronal toxicity of both mature fibres and oligomeric species, as well as the intracellular localization of the protein and the difficulty to be secreted, could be key factors impeding the prion ability of 𝛼-syn aggregates.
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It is part of: BioMed Research International, 2015, vol. 2015, p. 7 pp
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ISSN: 2314-6133
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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