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Title: Clostridioides difficile infection recurrence in the VINCat hospitals: a prospective observational cohort study
Author: Pujol Rojo, Miquel
Limón, Enrique
Sopena, Nieves
López-Contreras, Joaquín
Castellà, Laia
Cuquet, Jordi
López-Sánchez, Maria
Pérez, Rafel
Gudiol González, Carlota
Coloma, Ana
Marimón, Mariló
Espinach, Joan
Andres, Marta
Martos, Purificación
Hernández, Sergi
Almendral, Alexander
Saliba, Patrick
Carvalho Rodrigues, Gonçalo
Calbo, Esther
Keywords: Colitis
Efectes secundaris dels medicaments
Higiene hospitalària
Drug side effects
Hospital hygiene
Issue Date: 30-Sep-2022
Publisher: Future Medicine
Abstract: Background: The 2016 cumulative incidence of Clostridioides difficile infection (CDI) in Spain was reported by the European Center for Disease Control to be above the mean of other European countries. The aim of this multicenter prospective observational cohort study was to examine the risk factors that determine 90-day CDI recurrence in Catalonia, Spain. Methods: The study included 558 consecutive adults admitted to hospital who had a symptomatic, first positive CDI diagnosis. Sociodemographic, clinical and epidemiological variables were recorded. The primary outcome was 90-day CDI recurrence. Results: In this Catalan population, having received more than one course of antibiotics in the 30 days prior to CDI diagnosis (odds ratio: 2.459; 95% CI: 1.195-5.060; p = 0.015) and active chemotherapy (odds ratio: 4.859; 95% CI: 1.495-15.792; p = 0.009) are significant predictors of 90-day CDI recurrence. Conclusion: The identification of independent risk factors of 90-day CDI recurrence will enable the optimization of preventive measures in at-risk populations.
Note: Versió postprint del document publicat a:
It is part of: Future Microbiology, 2022, num. 17, p. 1445-1453
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ISSN: 1746-0913
Appears in Collections:Articles publicats en revistes (Infermeria de Salut Pública, Salut mental i Maternoinfantil)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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