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Title: | Major Adverse Cardiovascular Events in Coronary Type 2 Diabetic Patients: Identification of Associated Factors Using Electronic Health Records and Natural Language Processing |
Author: | González Juanatey, Carlos Anguita Sánchez, Manuel Barrios, Vivencio Núñez Gil, Iván Gómez Doblas, Juan José García Moll, Xavier Lafuente Gormaz, Carlos Rollán Gómez, María Jesús Peral Disdier, Vicente Martínez Dolz, Luis Rodríguez Santamarta, Miguel Viñolas Prat, Xavier Soriano Colomé, Toni Muñoz Aguilera, Roberto Plaza, Ignacio Curcio Ruigómez, Alejandro Orts Soler, Ernesto Segovia, Javier Fanjul, Víctor Cequier Fillat, Àngel R. Savana Research Group |
Keywords: | Diabetis Tractament del llenguatge natural (Informàtica) Diabetes Natural language processing (Computer science) |
Issue Date: | 11-Oct-2022 |
Publisher: | MDPI AG |
Abstract: | Patients with Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) are at high risk of developing major adverse cardiovascular events (MACE). This is a multicenter, retrospective, and observational study performed in Spain aimed to characterize these patients in a real-world setting. Unstructured data from the Electronic Health Records were extracted by EHRead (R), a technology based on Natural Language Processing and machine learning. The association between new MACE and the variables of interest were investigated by univariable and multivariable analyses. From a source population of 2,184,662 patients, we identified 4072 adults diagnosed with T2DM and CAD (62.2% male, mean age 70 +/- 11). The main comorbidities observed included arterial hypertension, hyperlipidemia, and obesity, with metformin and statins being the treatments most frequently prescribed. MACE development was associated with multivessel (Hazard Ratio (HR) = 2.49) and single coronary vessel disease (HR = 1.71), transient ischemic attack (HR = 2.01), heart failure (HR = 1.32), insulin treatment (HR = 1.40), and percutaneous coronary intervention (PCI) (HR = 2.27), whilst statins (HR = 0.73) were associated with a lower risk of MACE occurrence. In conclusion, we found six risk factors associated with the development of MACE which were related with cardiovascular diseases and T2DM severity, and treatment with statins was identified as a protective factor for new MACE in this study. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jcm11206004 |
It is part of: | Journal of Clinical Medicine, 2022, vol. 11, núm. 20, p. 6004 |
URI: | http://hdl.handle.net/2445/191195 |
Related resource: | https://doi.org/10.3390/jcm11206004 |
ISSN: | 2077-0383 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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jcm-11-06004-v3.pdf | 1.2 MB | Adobe PDF | View/Open |
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