Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/191362
Title: | Genetically predicted telomere length and Alzheimer’s disease endophenotypes: a Mendelian randomization study |
Author: | Rodríguez Fernández, Blanca Vilor Tejedor, Natalia Arenaza Urquijo, Eider M. Sánchez Benavides, Gonzalo Suárez Calvet, Marc Operto, Grégory Minguillón, Carolina Fauria, Karine Kollmorgen, Gwendlyn Suridjan, Ivonne Castro de Moura, Manuel Piñeyro, David Esteller, Manel Blennow, Kaj Zetterberg, Henrik Vivo, Immaculata de Molinuevo, José Luis Navarro, Arcadi Gispert, Juan Domingo Sala Vila, Aleix Crous Bou, Marta Akinci, Müge Beteta, Annabella Brugulat Serrat, Anna Cacciaglia, Raffaele Cañas, Alba Cumplido, Irene Deulofeu, Carme Dominguez, Ruth Emilio, Maria Falcon, Carles Fuentes, Sherezade Grau Rivera, Oriol González de Echávarri, José M. Hernandez, Laura Genius, Patricia Huesa, Gema Huguet, Jordi Palacios, Eva M. Marne, Paula Menchón, Tania Milà Alomà, Marta Peña Gomez, Cleofé Polo, Albina Pradas, Sandra Salvadó, Gemma Shekari, Mahnaz Soteras, Anna Stankeviciute, Laura Vilanova, Marc The Alfa Study |
Keywords: | Malaltia d'Alzheimer Telòmer Alzheimer's disease Telomere |
Issue Date: | 7-Nov-2022 |
Publisher: | Springer Science and Business Media LLC |
Abstract: | Telomere length (TL) is associated with biological aging, consequently influencing the risk of age-related diseases such as Alzheimer's disease (AD). We aimed to evaluate the potential causal role of TL in AD endophenotypes (i.e., cognitive performance, N = 2233; brain age and AD-related signatures, N = 1134; and cerebrospinal fluid biomarkers (CSF) of AD and neurodegeneration, N = 304) through a Mendelian randomization (MR) analysis. Our analysis was conducted in the context of the ALFA (ALzheimer and FAmilies) study, a population of cognitively healthy individuals at risk of AD. A total of 20 single nucleotide polymorphisms associated with TL were used to determine the effect of TL on AD endophenotypes. Analyses were adjusted by age, sex, and years of education. Stratified analyses by APOE-epsilon 4 status and polygenic risk score of AD were conducted. MR analysis revealed significant associations between genetically predicted longer TL and lower levels of CSF A beta and higher levels of CSF NfL only in APOE-epsilon 4 non-carriers. Moreover, inheriting longer TL was associated with greater cortical thickness in age and AD-related brain signatures and lower levels of CSF p-tau among individuals at a high genetic predisposition to AD. Further observational analyses are warranted to better understand these associations. |
Note: | Reproducció del document publicat a: https://doi.org/10.1186/s13195-022-01101-9 |
It is part of: | Alzheimer's Research & Therapy, 2022, vol. 14, núm. 167 |
URI: | https://hdl.handle.net/2445/191362 |
Related resource: | https://doi.org/10.1186/s13195-022-01101-9 |
ISSN: | 1758-9193 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
s13195-022-01101-9.pdf | 3.34 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License