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http://hdl.handle.net/2445/191524
Title: | Inflammaging and blood pressure profiles in late life: the screening for CKD among older people across Europe (SCOPE) study |
Author: | Tap, Lisanne Corsonello, Andrea Rosa, Mirko Di Fabbietti, Paolo Formiga Pérez, Francesc Moreno González, Rafael Ärnlöv, Johan Carlsson, Axel C. Polinder-Bos, Harmke A. Roller-Wirnsberger, Regina Wirnsberger, Gerhard Kostka, Tomasz Guligowska, Agnieszka Artzi-Medvedik, Rada Yehoshua, Ilian Weingart, Christian Sieber, Cornel Gil, Pedro Lainez Martinez, Sara Lattanzio, Fabrizia |
Keywords: | Inflamació Hipertensió Pressió sanguínia Persones grans Inflammation Hypertension Blood pressure Older people |
Issue Date: | 8-Dec-2022 |
Publisher: | MDPI |
Abstract: | The neutrophil-to-lymphocyte ratio (NLR) is a marker for systemic inflammation. Since inflammation plays a relevant role in vascular aging, the aim of this study was to investigate whether NLR is associated with blood pressure profiles in older adults. This study was performed within the framework of the SCOPE study including 2461 outpatients aged 75 years and over. Mean blood pressure values, namely systolic blood pressure (SBP), diastolic blood pressure (DBP) and pulse pressure (PP) were investigated across tertiles of NLR. Change in blood pressure levels in 2 years of follow-up were compared across categories of baseline NLR. Data of 2397 individuals were used, of which 1854 individuals had hypertension. Mean values of blood pressure did not differ across categories of baseline NLR in individuals without hypertension. Individuals with hypertension with a high-range NLR had lower SBP and PP when compared to those in low-range NLR (mean difference SBP −2.94 mmHg, p = 0.032 and PP −2.55 mmHg, p = 0.030). Mean change in blood pressure in 2 years did only slightly differ in non-clinically relevant ranges, when compared across tertiles of baseline NLR. NLR as a marker of inflammaging was not associated with unfavorable blood pressure profiles in older individuals with or without hypertension. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jcm11247311 |
It is part of: | Journal of Clinical Medicine, 2022, vol. 11, num. 24 |
URI: | http://hdl.handle.net/2445/191524 |
Related resource: | https://doi.org/10.3390/jcm11247311 |
ISSN: | 2077-0383 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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