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DC Field | Value | Language |
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dc.contributor.author | Josa Laorden, Claudia | - |
dc.contributor.author | Rubio Gracia, Jorge | - |
dc.contributor.author | Sánchez Marteles, Marta | - |
dc.contributor.author | Torcal, Pilar | - |
dc.contributor.author | Garcés Horna, Vanesa | - |
dc.contributor.author | Sola Martínez, Anna | - |
dc.contributor.author | Íñigo, Pablo | - |
dc.contributor.author | Giménez López, Ignacio | - |
dc.contributor.author | Pérez Calvo, Juan Ignacio | - |
dc.date.accessioned | 2022-12-23T08:55:43Z | - |
dc.date.available | 2022-12-23T08:55:43Z | - |
dc.date.issued | 2022-07-01 | - |
dc.identifier.issn | 1897-9483 | - |
dc.identifier.uri | http://hdl.handle.net/2445/191813 | - |
dc.description.abstract | INTRODUCTION Hospitalization for acute decompensation of heart failure (ADHF) is a frequent event associated with long-term adverse effects. Prognosis is even worse if acute kidney injury (AKI) occurs during hospitalization.OBJECTIVES The study aimed to determine whether kidney damage biomarkers neutrophil gelatinase--associatedlipocalin (NGAL), kidney injury molecule 1 (KIM-1), and interleukin 18 (IL-18) might predict AKI and have prognostic value in ADHF.PATIENTS AND METHODS Serum NGAL on admission and urine NGAL, KIM-1, and IL-18 on discharge were determined in 187 ADHF patients enrolled in a prospective, observational, unblinded study. AKI was diagnosed using the Kidney Disease: Improving Global Outcomes criteria. Patients were followed for 12 months to record all-cause mortality.RESULTS A total of 22% patients died during the follow-up, with 52.5% dying within 4 months after discharge. Serum NGAL (P <0.001), urine NGAL (P = 0.047), and urinary KIM-1 (P = 0.014) levels were significantly higher in the deceased patients at discharge. After adjustment for estimated glomerular filtration rate (eGFR), only urinary KIM-1 independently predicted mortality at month 4 (hazard ratio [HR], 3.166; 95% CI, 1.203-8.334; P = 0.020) and month 12 (HR, 1.969; 95% CI, 1.123-3.454; P = 0.018) in Cox regression models. In receiver operating characteristic (ROC) analysis urinary KIM-1 (area under the ROC curve [AUC] = 0.830) outperformed other markers of renal function. The Kaplan-Meier sur-vival analysis showed KIM-1 predictive value as additive to that of AKI incidence and admission eGFR. Admission serum NGAL was higher in AKI patients (P <= 0.001) with a modest diagnostic performance (AUC = 0.667), below that of urea (AUC = 0.732), creatinine (AUC = 0.696), or cystatin C (AUC = 0.676).CONCLUSIONS Discharge urinary KIM-1 was a strong and independent predictor of mortality, particularly during the most vulnerable period shortly after hospitalization. Admission serum NGAL was inferior to conventional renal function parameters in predicting AKI during ADHF. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Medycyna Praktyczna Spolka Jawna | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.20452/pamw.16284 | - |
dc.relation.ispartof | Polish Archives of Internal Medicine, 2022, vol. 132, num. 9 | - |
dc.relation.uri | https://doi.org/10.20452/pamw.16284 | - |
dc.rights | cc by-nc-sa (c) Josa Laorden, Claudia et al, 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Insuficiència renal aguda | - |
dc.subject.classification | Insuficiencia cardíaca | - |
dc.subject.other | Acute renal failure | - |
dc.subject.other | Heart failure | - |
dc.title | Elevated urinary Kidney Injury Molecule 1 (KIM-1) at discharge strongly predicts early mortality following an episode of acute decompensated heart failure | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2022-12-19T12:15:05Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 35785920 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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PAIM-22-00085_Gimenez_orig.pdf | 610.38 kB | Adobe PDF | View/Open |
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