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Title: SARS-CoV-2 viral load analysis at low and high altitude: A case study from Ecuador
Author: Ortiz-Prado, Esteban
Simbaña-Rivera, Katherine
Fernández Naranjo, Raúl
Vásconez González, Jorge Eduardo
Henríquez-Trujillo, Aquiles R.
Vallejo-Janeta, Alexander Paolo
Rivera-Olivero, Ismar A.
Lozada, Tannya
Viscor Carrasco, Ginés
Garcia-Bereguiain, Miguel Angel
Keywords: COVID-19
Influència de l'altitud
Influence of altitude
Issue Date: 28-Jun-2022
Publisher: MDPI
Abstract: SARS-CoV-2 has spread throughout the world, including remote areas such as those located at high altitudes. There is a debate about the role of hypobaric hypoxia on viral transmission and COVID-19 incidence. A descriptive cross-sectional analysis of SARS-CoV-2 infection and viral load among patients living at low (230 m) and high altitude (3800 m) in Ecuador was completed. Within these two communities, the total number of infected people at the time of the study was 108 cases (40.3%). The COVID-19 incidence proportion at low altitude was 64% while at high altitude was 30.3%. The mean viral load from those patients who tested positive was 3,499,184 copies/mL (SD = 23,931,479 copies/mL). At low altitude (Limoncocha), the average viral load was 140,223.8 copies/mL (SD = 990,840.9 copies/mL), while for the high altitude group (Oyacachi), the mean viral load was 6,394,789 copies/mL (SD = 32,493,469 copies/mL). We found no statistically significant differences when both results were compared (p = 0.056). We found no significant differences across people living at low or high altitude; however, men and younger populations had higher viral load than women older populations, respectively
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It is part of: International Journal of Environmental Research and Public Health, 2022, vol. 19, num. 13, p. e7945
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ISSN: 1661-7827
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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