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Title: Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort
Author: Gil Lespinard, Mercedes
Castañeda, Jazmín
Almanza Aguilera, Enrique
Gómez, Jesús Humberto
Tjønneland, Anne
Kyrø, Cecilie
Overvad, Kim
Katzke, Verena
Schulze, Matthias B.
Masala, Giovanna
Agnoli, Claudia
Santucci de Magistris, Maria
Tumino, Rosario
Sacerdote, Carlotta
Skeie, Guri
Lasheras, Cristina
Molina Montes, Esther
Huerta, José María
Barricarte, Aurelio
Amiano, Pilar
Sonestedt, Emily
Da Silva, Marisa
Johansson, Ingegerd
Hultdin, Johan
May, Anne M.
Forouhi, Nita G.
Heath, Alicia K.
Freisling, Heinz
Weiderpass, Elisabete
Scalbert, Augustin
Zamora-Ros, Raul
Keywords: Polifenols
Pes corporal
Estrès oxidatiu
Body weight
Oxidative stress
Issue Date: 8-Dec-2022
Publisher: MDPI AG
Abstract: Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association with 5-year body weight change in a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 349,165 adult participants from nine European countries. Polyphenol intake was estimated through country-specific validated dietary questionnaires and the Phenol-Explorer database. Body weight was obtained at recruitment and after a mean follow-up time of 5 years. Associations were estimated using multilevel mixed linear regression models. From 91 polyphenols included, the majority (n = 67) were inversely associated with 5-year body weight change after FDR-correction (q < 0.05). The greatest inverse associations were observed for quercetin 3-O-rhamnoside (change in weight for doubling in intake: -0.071 (95% CI: -0.085; -0.056) kg/5 years). Only 13 polyphenols showed positive associations with body weight gain, mainly from the subclass hydroxycinnamic acids (HCAs) with coffee as the main dietary source, such as 4-caffeoylquinic acid (0.029 (95% CI: 0.021; 0.038) kg/5 years). Individual polyphenols with fruit, tea, cocoa and whole grain cereals as the main dietary sources may contribute to body weight maintenance in adults. Individual HCAs may have different roles in body weight change depending on their dietary source.
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It is part of: Antioxidants, 2022, vol. 11, num. 12, p. 2425
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ISSN: 2076-3921
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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