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Title: | Dietary Intake of 91 Individual Polyphenols and 5-Year Body Weight Change in the EPIC-PANACEA Cohort |
Author: | Gil Lespinard, Mercedes Castañeda, Jazmín Almanza Aguilera, Enrique Gómez, Jesús Humberto Tjønneland, Anne Kyrø, Cecilie Overvad, Kim Katzke, Verena Schulze, Matthias B. Masala, Giovanna Agnoli, Claudia Santucci de Magistris, Maria Tumino, Rosario Sacerdote, Carlotta Skeie, Guri Lasheras, Cristina Molina Montes, Esther Huerta, José María Barricarte, Aurelio Amiano, Pilar Sonestedt, Emily Da Silva, Marisa Johansson, Ingegerd Hultdin, Johan May, Anne M. Forouhi, Nita G. Heath, Alicia K. Freisling, Heinz Weiderpass, Elisabete Scalbert, Augustin Zamora-Ros, Raul |
Keywords: | Polifenols Pes corporal Obesitat Estrès oxidatiu Polyphenols Body weight Obesity Oxidative stress |
Issue Date: | 8-Dec-2022 |
Publisher: | MDPI AG |
Abstract: | Polyphenols are bioactive compounds from plants with antioxidant properties that may have a protective role against body weight gain, with adipose tissue and systemic oxidative stress as potential targets. We aimed to investigate the dietary intake of individual polyphenols and their association with 5-year body weight change in a sub-cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 349,165 adult participants from nine European countries. Polyphenol intake was estimated through country-specific validated dietary questionnaires and the Phenol-Explorer database. Body weight was obtained at recruitment and after a mean follow-up time of 5 years. Associations were estimated using multilevel mixed linear regression models. From 91 polyphenols included, the majority (n = 67) were inversely associated with 5-year body weight change after FDR-correction (q < 0.05). The greatest inverse associations were observed for quercetin 3-O-rhamnoside (change in weight for doubling in intake: -0.071 (95% CI: -0.085; -0.056) kg/5 years). Only 13 polyphenols showed positive associations with body weight gain, mainly from the subclass hydroxycinnamic acids (HCAs) with coffee as the main dietary source, such as 4-caffeoylquinic acid (0.029 (95% CI: 0.021; 0.038) kg/5 years). Individual polyphenols with fruit, tea, cocoa and whole grain cereals as the main dietary sources may contribute to body weight maintenance in adults. Individual HCAs may have different roles in body weight change depending on their dietary source. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/antiox11122425 |
It is part of: | Antioxidants, 2022, vol. 11, num. 12, p. 2425 |
URI: | http://hdl.handle.net/2445/192249 |
Related resource: | https://doi.org/10.3390/antiox11122425 |
ISSN: | 2076-3921 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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