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http://hdl.handle.net/2445/192265
Title: | Methods for Stratification and Validation Cohorts: A Scoping Review |
Author: | Torres Moral, Teresa Sánchez Niubò, Albert Monistrol-Mula, Anna Gerardi, Chiara Banzi, Rita Garcia, Paula Demotes-Mainard, Jacques Haro Abad, Josep Maria |
Keywords: | Medicina personalitzada Ressenyes sistemàtiques (Investigació mèdica) Personalized medicine Systematic reviews (Medical research) |
Issue Date: | 26-Apr-2022 |
Publisher: | MDPI |
Abstract: | Personalized medicine requires large cohorts for patient stratification and validation of patient clustering. However, standards and harmonized practices on the methods and tools to be used for the design and management of cohorts in personalized medicine remain to be defined. This study aims to describe the current state-of-the-art in this area. A scoping review was conducted searching in PubMed, EMBASE, Web of Science, Psycinfo and Cochrane Library for reviews about tools and methods related to cohorts used in personalized medicine. The search focused on cancer, stroke and Alzheimer's disease and was limited to reports in English, French, German, Italian and Spanish published from 2005 to April 2020. The screening process was reported through a PRISMA flowchart. Fifty reviews were included, mostly including information about how data were generated (25/50) and about tools used for data management and analysis (24/50). No direct information was found about the quality of data and the requirements to monitor associated clinical data. A scarcity of information and standards was found in specific areas such as sample size calculation. With this information, comprehensive guidelines could be developed in the future to improve the reproducibility and robustness in the design and management of cohorts in personalized medicine studies. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/jpm12050688 |
It is part of: | Journal of Personalized Medicine, 2022, vol. 12, num. 5, p. 688 |
URI: | http://hdl.handle.net/2445/192265 |
Related resource: | https://doi.org/10.3390/jpm12050688 |
ISSN: | 2075-4426 |
Appears in Collections: | Articles publicats en revistes (Psicologia Social i Psicologia Quantitativa) |
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