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http://hdl.handle.net/2445/192288
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DC Field | Value | Language |
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dc.contributor.author | Solis, Oscar | - |
dc.contributor.author | Beccari, Andrea R. | - |
dc.contributor.author | Iaconis, Daniela | - |
dc.contributor.author | Talarico, Carmine | - |
dc.contributor.author | Ruiz Bedoya, Camilo A. | - |
dc.contributor.author | Nwachukwu, Jerome C. | - |
dc.contributor.author | Cimini, Annamaria | - |
dc.contributor.author | Castelli, Vanessa | - |
dc.contributor.author | Bertini, Riccardo | - |
dc.contributor.author | Montopoli, Monica | - |
dc.contributor.author | Cocetta, Veronica | - |
dc.contributor.author | Borocci, Stefano | - |
dc.contributor.author | Prandi, Ingrid G. | - |
dc.contributor.author | Flavahan, Kelly | - |
dc.contributor.author | Bahr, Melissa | - |
dc.contributor.author | Napiorkowski, Anna | - |
dc.contributor.author | Chillemi, Giovanni | - |
dc.contributor.author | Ooka, Masato | - |
dc.contributor.author | Yang, Xiaoping | - |
dc.contributor.author | Zhang, Shiliang | - |
dc.contributor.author | Xia, Menghang | - |
dc.contributor.author | Zheng, Wei | - |
dc.contributor.author | Bonaventura, Jordi | - |
dc.contributor.author | Pomper, Martin G. | - |
dc.contributor.author | Hooper, Jody E. | - |
dc.contributor.author | Morales, Marisela | - |
dc.contributor.author | Rosenberg, Avi Z. | - |
dc.contributor.author | Nettles, Kendall W. | - |
dc.contributor.author | Jain, Sanjay K. | - |
dc.contributor.author | Allegretti, Marcello | - |
dc.contributor.author | Michaelides, Michael | - |
dc.date.accessioned | 2023-01-18T17:43:21Z | - |
dc.date.available | 2023-01-18T17:43:21Z | - |
dc.date.issued | 2022-12-02 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | http://hdl.handle.net/2445/192288 | - |
dc.description.abstract | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein binds angiotensin-converting enzyme 2 as its primary infection mechanism. Interactions between S and endogenous proteins occur after infection but are not well understood. We profiled binding of S against >9000 human proteins and found an interaction between S and human estrogen receptor alpha (ER alpha). Using bioinformatics, supercomputing, and experimental assays, we identified a highly conserved and functional nuclear receptor coregulator (NRC) LXD-like motif on the S2 sub-unit. In cultured cells, S DNA transfection increased ER alpha cytoplasmic accumulation, and S treatment induced ER-dependent biological effects. Non-invasive imaging in SARS-CoV-2-infected hamsters localized lung pathology with increased ER alpha lung levels. Postmortem lung experiments from infected hamsters and humans confirmed an increase in cytoplasmic ER alpha and its colocalization with S in alveolar macrophages. These findings describe the discovery of a S-ER alpha interaction, imply a role for S as an NRC, and advance knowledge of SARS-CoV-2 biology and coronavirus disease 2019 pathology. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Association for the Advancement of Science (AAAS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1126/sciadv.add4150 | - |
dc.relation.ispartof | Science Advances, 2022, vol. 8, num. 48, p. eadd4150 | - |
dc.relation.uri | https://doi.org/10.1126/sciadv.add4150 | - |
dc.rights | cc by-nc (c) Solis, Oscar et al., 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | SARS-CoV-2 | - |
dc.subject.classification | Pandèmia de COVID-19, 2020- | - |
dc.subject.classification | Fixació de proteïnes | - |
dc.subject.other | SARS-CoV-2 | - |
dc.subject.other | COVID-19 Pandemic, 2020- | - |
dc.subject.other | Protein binding | - |
dc.title | The SARS-CoV-2 spike protein binds and modulates estrogen receptors | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-01-16T12:11:44Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 35665018 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Neurociències (UBNeuro)) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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sciadv.add4150.pdf | 8.72 MB | Adobe PDF | View/Open |
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