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http://hdl.handle.net/2445/192290
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DC Field | Value | Language |
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dc.contributor.author | Vázquez Sánchez, Daniel Antonio | - |
dc.contributor.author | Grillo, Sara | - |
dc.contributor.author | Carrera Salinas, Anna | - |
dc.contributor.author | González Díaz, Aida | - |
dc.contributor.author | Cuervo Requena, Guillermo | - |
dc.contributor.author | Grau, Inmaculada | - |
dc.contributor.author | Camoez, Mariana | - |
dc.contributor.author | Martí, Sara | - |
dc.contributor.author | Berbel, Dàmaris | - |
dc.contributor.author | Tubau, Fe | - |
dc.contributor.author | Ardanuy Tisaire, María Carmen | - |
dc.contributor.author | Pujol, Miquel | - |
dc.contributor.author | Càmara, Jordi | - |
dc.contributor.author | Domínguez Luzón, Ma. Ángeles (María Ángeles) | - |
dc.date.accessioned | 2023-01-18T17:46:41Z | - |
dc.date.available | 2023-01-18T17:46:41Z | - |
dc.date.issued | 2022-12-03 | - |
dc.identifier.issn | 2076-2607 | - |
dc.identifier.uri | http://hdl.handle.net/2445/192290 | - |
dc.description.abstract | Methicillin-resistant Staphylococcus aureus bloodstream infections (MRSA-BSI) are a significant cause of mortality. We analysed the evolution of the molecular and clinical epidemiology of MRSA-BSI (n = 784) in adult patients (Barcelona, 1990-2019). Isolates were tested for antimicrobial susceptibility and genotyped (PFGE), and a selection was sequenced (WGS) to characterise the pangenome and mechanisms underlying antimicrobial resistance. Increases in patient age (60 to 71 years), comorbidities (Charlson's index > 2, 10% to 94%), community-onset healthcare-associated acquisition (9% to 60%), and 30-day mortality (28% to 36%) were observed during the 1990-1995 and 2014-2019 periods. The proportion of catheter-related BSIs fell from 57% to 20%. Current MRSA-BSIs are caused by CC5-IV and an upward trend of CC8-IV and CC22-IV clones. CC5 and CC8 had the lowest core genome proportions. Antimicrobial resistance rates fell, and only ciprofloxacin, tobramycin, and erythromycin remained high (>50%) due to GyrA/GrlA changes, the presence of aminoglycoside-modifying enzymes (AAC(6 ')-Ie-APH(2 '')-Ia and ANT(4 ')-Ia), and mph(C)/msr(A) or erm (C) genes. Two CC22-IV strains showed daptomycin resistance (MprF substitutions). MRSA-BSI has become healthcare-associated, affecting elderly patients with comorbidities and causing high mortality rates. Clonal replacement with CC5-IV and CC8-IV clones resulted in lower antimicrobial resistance rates. The increased frequency of the successful CC22-IV, associated with daptomycin resistance, should be monitored. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI AG | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/microorganisms10122401 | - |
dc.relation.ispartof | Microorganisms, 2022, vol. 10, num. 12, p. 2401 | - |
dc.relation.uri | https://doi.org/10.3390/microorganisms10122401 | - |
dc.rights | cc by (c) Vázquez Sánchez, Daniel Antonio et al., 2022 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Staphylococcus aureus | - |
dc.subject.classification | Epidemiologia molecular | - |
dc.subject.classification | Agents antiinfecciosos | - |
dc.subject.classification | Resistència als medicaments | - |
dc.subject.other | Staphylococcus aureus | - |
dc.subject.other | Molecular epidemiology | - |
dc.subject.other | Anti-infective agents | - |
dc.subject.other | Drug resistance | - |
dc.title | Molecular Epidemiology, Antimicrobial Susceptibility, and Clinical Features of Methicillin-Resistant Staphylococcus aureus Bloodstream Infections over 30 Years in Barcelona, Spain (1990–2019) | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-01-16T11:39:41Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 36557654 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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microorganisms-10-02401.pdf | 2.52 MB | Adobe PDF | View/Open |
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