Title: | Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses |
Author: | Gaziano, Liam Sun, Luanluan Arnold, Matthew Bell, Steven Cho, Kelly Kaptoge, Stephen K. Song, Rebecca J. Burgess, Stephen Posner, Daniel C. Mosconi, Katja Robinson Cohen, Cassianne Danesh, John Whincup, Peter Hayama Terada, Mina Tybjaerg Hansen, Anne Iso, Hiroyasu Tunstall Pedoe, Hugh Damrauer, Scott M. Joseph, Jacob Pennells, Lisa Di Angelantonio, Emanuele Altay, Servet Staley, James R. Wilson, Peter W.F. Harrison, Seamus Willeit, Peter Kronmal, Richard Willeit, Johann Amiano, Pilar Woodward, Mark Koettgen, Anna Shaw, Jonathan Cooper, Jackie A. Afzal, Shoaib Shimbo, Daichi Lora Pablos, David Casiglia, Edoardo Bolton, Thomas R. Leitner, Christoph Casiglia, Edoardo Freisling, Heinz Chetrit, Angela Völzke, Henry Gagnon, David R. Welin, Lennart Donfrancesco, Chiara Martin Arriscado, Cristina Romero Ferreiro, Carmen Wallace, Robert B. Kaaks, Rudolf Norman, Paul E. Tao, Ran Wareham, Nick Almeida, Osvaldo Engström, Gunnar Imano, Hironori Svärdsudd, Kurt Welin, Lennart Svärdsudd, Kurt Masala, Giovanna Tuomainen, Tomi Pekka Lissner, Lauren Tong, Tammy Van Zutphen, E. M. Jassal, Simerjot K. Pyarajan, Saiju Lawlor, Deborah A. Flicker, Leon Hata, Jun Honda, Takanori Rosengren, Annika Nilsson, Peter M. Furuta, Yoshihiko Akwo, Elvis A. Melander, Olle MacDonald, Conor Gaziano, Thomas A. Langenberg, Claudia Onland Moret, Charlotte Van Schoor, N. M. Donfrancesco, Chiara Lo Noce, Cinzia Van Der Schouw, Yvonne T. Aspelund, Thor Palmieri, Luigi Casas, Juan P. Thorsson, Bolli Ärnlöv, Johan Quirós Garcia, Jose Ramón Arndt, Volker Petrova, Dafina Tikhonoff, Valérie Hedblad, Bo Nitsch, Dorothea Cooper, Jackie A. Tsao, Philip S. Morikawa, Yuko Shaffer, Jonathan Arndt, Volker Ljungberg, Börje Ishizaki, Masao Ärnlöv, Johan Tzoulaki, Ioanna Chiodini, Paolo Tumino, Rosario Woodward, Mark Sigurdsson, Gunnar Chaker, Layal Ikram, Kamran M. Feskens, Edith Riboli, Elio Staplin, Natalie Kavousi, Maryam Barr, Elizabeth L.M. Palmieri, Luigi Björkelund, Cecilia Hung, Adriana M. Yamagishi, Kazumasa Geleijnse, Johanna M Kromhout, Daan Coresh, Josef Tjønneland, Anne Cushman, Mary Atkins, Robert C. Inouye, Michael Boer, Jolanda M.A. Brenner, Hermann Schnohr, Peter Gómez de la Cámara, Agustín Zamora-Ros, Raul Gudnason, Vilmundur Tikhonoff, Valérie Dankner, Rachel Davidson, Karina W. De Jongh, Renate T. Holleczek, Bernd Katzke, Verena Baigent, Colin Özkan, Uğur Kauhanen, Jussi Stocker, Hannah Hankey, Graeme J. Hansson, Per-Olof Heath, Alicia K. Nagel, Dorothea Meisinger, Christa Hoorn, Ewout J. Chen, Lingyan Melander, Olle Schöttker, Ben Hange, Dominique Kiechl, Stefan Koenig, Wolfgang Kronmal, Richard A. Salonen, Jukka T. Sacerdote, Carlotta Kyrø, Cecilie Sato, Shinichi Sakurai, Masaru Mehlig, Kirsten Yüksel, Hüsniye Iso, Hiroyasu Moreno Iribas, Conchi Ninomiya, Toshiharu Nitsch, Dorothea Lappas, Georg Verschuren, W.M. Monique Nordestgaard, Børge G. Can, Günay Völzke, Henry Muraki, Isao Mason, Amy M. Schubert, Petra Cushman, Mary Santiuste, Carmen Schulze, Matthias B. Sieri, Sabina Jassal, Simerjot Muralidhar, Sumitra Sundström, Johan Allara, Elias Edwards, Todd L. Butterworth, Adam S. Meisinger, Christa Zimmet, Paul Koenig, Wolfgang Schwartz, Joseph Wallace, Robert B. Goya Wannamethee, S. Weiderpass, Elisabete Nakagawa, Hideaki Gaziano, J.Michael Willeit, Peter Wood, Angela M. Kitamura, Akihiko |
Keywords: | Malalties cardiovasculars Malalties coronàries Malalties del ronyó Cardiovascular diseases Coronary diseases Kidney diseases |
Issue Date: | 15-Nov-2022 |
Publisher: | Ovid Technologies (Wolters Kluwer Health) |
Abstract: | BACKGROUND: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke. METHODS: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and Nutrition-Cardiovascular Disease Study], Million Veteran Program, and UK Biobank), comprising 648 135 participants with no history of cardiovascular disease or diabetes at baseline, yielding 42 858 and 15 693 incident CHD and stroke events, respectively, during 6.8 million personyears of follow-up. Using a genetic risk score of 218 variants for estimated glomerular filtration rate (eGFR), we conducted Mendelian randomization analyses involving 413 718 participants (25917 CHD and 8622 strokes) in EPIC-CVD, Million Veteran Program, and UK Biobank. RESULTS: There were U-shaped observational associations of creatinine-based eGFR with CHD and stroke, with higher risk in participants with eG FR values <60 or >105 mL.min(-1).1.73 m(-2), compared with those with eG FR between 60 and 105 mL.min(-1).1.73 m(-2). Mendelian randomization analyses for CHD showed an association among participants with eGFR <60 mL.min(-1).1.73 m(-2), with a 14% (95% CI, 3%-27%) higher CHD risk per 5 mL.min(-1).1.73 m(-2) lower genetically predicted eG FR, but not for those with eG FR >105 mL.min(-1).1.73 m(-2). Results were not materially different after adjustment for factors associated with the eGFR genetic risk score, such as lipoprotein(a), triglycerides, hemoglobin Alc, and blood pressure. Mendelian randomization results for stroke were nonsignificant but broadly similar to those for CHD. CONCLUSIONS: In people without manifest cardiovascular disease or diabetes, mild-to-moderate kidney dysfunction is causally related to risk of CHD, highlighting the potential value of preventive approaches that preserve and modulate kidney function. |
Note: | Reproducció del document publicat a: https://doi.org/10.1161/CIRCULATIONAHA.122.060700 |
It is part of: | Circulation, 2022, vol. 146, num. 20, p. 1507-1517 |
URI: | http://hdl.handle.net/2445/192294 |
Related resource: | https://doi.org/10.1161/CIRCULATIONAHA.122.060700 |
ISSN: | 0009-7322 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
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