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http://hdl.handle.net/2445/192640
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DC Field | Value | Language |
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dc.contributor.author | Riba Baqués, Marta | - |
dc.contributor.author | Valle i Macià, Jaume del | - |
dc.contributor.author | Molina Porcel, Laura | - |
dc.contributor.author | Pelegrí i Gabaldà, Carme | - |
dc.contributor.author | Vilaplana i Hortensi, Jordi | - |
dc.date.accessioned | 2023-01-26T08:06:20Z | - |
dc.date.available | 2023-01-26T08:06:20Z | - |
dc.date.issued | 2022-11-21 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/2445/192640 | - |
dc.description.abstract | In different organs and tissues, the lymphatic system serves as a drainage system for interstitial fluid and is useful for removing substances that would otherwise accumulate in the interstitium. In the brain, which lacks lymphatic circulation, the drainage and cleaning function is performed by the glymphatic system, called so for its dependence on glial cells and its similar function to that of the lymphatic system. In the present article, we define glymphatic insufficiency as the inability of the glymphatic system to properly perform the brain cleaning function. Furthermore, we propose that corpora amylacea or wasteosomes, which are protective structures that act as waste containers and accumulate waste products, are, in fact, a manifestation of chronic glymphatic insufficiency. Assuming this premise, we provide an explanation that coherently links the formation, distribution, structure, and function of these bodies in the human brain. Moreover, we open up new perspectives in the study of the glymphatic system since wasteosomes can provide information about which variables have the greatest impact on the glymphatic system and which diseases occur with chronic glymphatic insufficiency. For example, based on the presence of wasteosomes, it seems that aging, sleep disorders, and cerebrovascular pathologies have the highest impact on the glymphatic system, whereas neurodegenerative diseases have a more limited impact. Furthermore, as glymphatic insufficiency is a risk factor for neurodegenerative diseases, information provided by wasteosomes could help to define the strategies and actions that can prevent glymphatic disruptions, thus limiting the risk of developing neurodegenerative diseases. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | National Academy of Sciences | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://www.pnas.org/doi/10.1073/pnas.2211326119; https://www.pnas.org/doi/10.1073/pnas.2211326119 | - |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America - PNAS, 2022, vol. 119, num. 48, p. e2211326119 | - |
dc.rights | (c) Riba Baques, Marta et al., 2022 | - |
dc.source | Articles publicats en revistes (Bioquímica i Fisiologia) | - |
dc.subject.classification | Envelliment cerebral | - |
dc.subject.classification | Malalties neurodegeneratives | - |
dc.subject.classification | Immunitat | - |
dc.subject.other | Aging brain | - |
dc.subject.other | Neurodegenerative Diseases | - |
dc.subject.other | Immunity | - |
dc.title | Wasteosomes (corpora amylacea) as a hallmark of chronic glymphatic insufficiency | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 727129 | - |
dc.date.updated | 2023-01-26T08:06:20Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Fisiologia) |
Files in This Item:
File | Description | Size | Format | |
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727129.pdf | 3.78 MB | Adobe PDF | View/Open |
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