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Title: | Non-G Base Tetrads |
Author: | Escaja Sánchez, Nuria Mir Morro, Bartomeu Garavís, Miguel González, Carlos |
Keywords: | ADN RNA DNA RNA |
Issue Date: | 19-Aug-2022 |
Publisher: | MDPI |
Abstract: | Tetrads (or quartets) are arrangements of four nucleobases commonly involved in the stability of four-stranded nucleic acids structures. Four-stranded or quadruplex structures have attracted enormous attention in the last few years, being the most extensively studied guanine quadruplex (G-quadruplex). Consequently, the G-tetrad is the most common and well-known tetrad. However, this is not the only possible arrangement of four nucleobases. A number of tetrads formed by the different nucleobases have been observed in experimental structures. In most cases, these tetrads occur in the context of G-quadruplex structures, either inserted between G-quartets, or as capping elements at the sides of the G-quadruplex core. In other cases, however, non-G tetrads are found in more unusual four stranded structures, such as i-motifs, or different types of peculiar fold-back structures. In this report, we review the diversity of these non-canonical tetrads, and the structural context in which they have been found. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/molecules27165287 |
It is part of: | Molecules, 2022, vol. 27, num. 16, p. 5287 |
URI: | http://hdl.handle.net/2445/192701 |
Related resource: | https://doi.org/10.3390/molecules27165287 |
ISSN: | 1420-3049 |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
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