Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/192811
Title: | Variation in Nicotine Metabolization According to Biological Factors and Type of Nicotine Consumer |
Author: | Pérez Martín, Hipólito Lidón Moyano, Cristina González Marrón, Adrián Fu, Marcela Pérez Ortuño, Raúl Ballbè, Montse Martín Sánchez, Juan Carlos Pascual, José A. Fernández Muñoz, Esteve Martínez Sánchez, Jose M. |
Keywords: | Nicotina Metabolisme Cigarretes electròniques Hàbit de fumar Nicotine Metabolism Electronic cigarettes Smoking |
Issue Date: | 6-Jan-2023 |
Publisher: | MDPI AG |
Abstract: | This study aims to describe the nicotine metabolite ratio among tobacco smokers and electronic cigarette (e-cigarette) users and nonusers. We analyzed pooled data from a longitudinal and a cross-sectional study of the adult population from the city of Barcelona. The final sample included information on 166 smokers, 164 e-cigarettes users with nicotine, 41 e-cigarette users without nicotine, 95 dual users (users of both products), and 508 nonusers. We used log-linear models to control for the potential confounding effect of the daily number of cigarettes smoked. Salivary nicotine metabolic rate assessment included the rate of nicotine metabolism (cotinine/nicotine) and the nicotine metabolite ratio (trans-3′-hydroxycotinine/cotinine). Exclusive users of e-cigarette without nicotine have the lowest rate of nicotine metabolism (Geometric mean: 0.08, p-values < 0.001) while cigarette smokers have the highest (Geometric mean: 2.08, p-values < 0.001). Nonusers have lower nicotine metabolic rate than cigarette smokers (Geometric means: 0.23 vs. 0.18, p-value < 0.05). Younger individuals (18–44 years) have a higher rate of nicotine metabolism than older individuals (45–64 years and 65–89) (Geometric means: 0.53 vs. 0.42 and 0.31, respectively, p-values < 0.01) and individuals with lower body mass index (21–25 kg/m2) have a higher rate of nicotine metabolism than the rest (26–30 kg/m2 and 31–60 kg/m2) (Geometric means: 0.52 vs. 0.35 and 0.36, respectively-values < 0.01). Nicotine metabolic rates are useful biomarkers when reporting smoking status and biological differences between individuals. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/healthcare11020179 |
It is part of: | Healthcare, 2023, vol. 11, num. 2, p. 179 |
URI: | http://hdl.handle.net/2445/192811 |
Related resource: | https://doi.org/10.3390/healthcare11020179 |
ISSN: | 2227-9032 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
healthcare-11-00179.pdf | 521.53 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License